Results about: chemotherapy

Genetic alterations caused by cancer therapies identified

Scientists at IRB Barcelona determine the genetic alterations in the cells of cancer patients caused by the main cancer therapies.

This is an important step towards understanding the long-term side effects and optimizing treatments against cancer.

The results have been published in the journal Nature Genetics.

P38MAM

New combination therapy for breast tumours, with selection marker

Researchers design a nano-carrier to release drugs into damaged cells

A team headed by Manuel Serrano at IRB Barcelona has designed a drug encapsulation system that selectively targets senescent cells.

The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.

Tumour cells evade death through in extremis DNA repair

A study on breast cancer conducted at IRB Barcelona identifies the key role of p38 in safeguarding tumour cells against the excessive accumulation of DNA damage, which would otherwise cause cell death.

p38 blockage has been shown to increase the death of tumour cells, thus causing tumours to shrink.

The combination of p38 inhibitors with chemotherapeutic drugs (taxanes) strengthens, accelerates or prolongs the antitumour effect in patient-derived tumours grown in mice.