Results about: chromatin
The recognition of many types of DNA lesions activates the cellular DNA damage response (DDR). The DDR orchestrates the appropriate cellular programs to maintain genome integrity after genotoxic stress.
Genomic functions take place in chromatin, not in naked DNA.
A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.
Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.
Genomic instability is the main risk factor for tumour development in humans. Therefore understanding its origin and exploring therapeutic targets is paramount.
Histone 1 silences a region of the genome that causes irreparable DNA damage when translated and is lethal for the organism.
Scientists in the Multiscale Complex Genomics (MuG) Consortium are working on new cloud-based computational infrastructure to support and improve the existing genome analysis tools. The beta-version of the Virtual Research Environment (VRE) was presented for the first time in Cambridge in April. MuG is a Horizon 2020 project coordinated by IRB Barcelona Group Leader Modesto Orozco.