Results about: developmental biology

BigH1—the key histone for male fertility

Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.

The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.

Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.

Embryonic development inspires regenerative medicine

The European Molecular Biology Lab (EMBL) in Barcelona and IRB Barcelona bring together leading scientists in the conference “Morphogenetic Engineering”, an event supported by the BBVA Foundation.

The merge of various disciplines of developmental biology is key to enhancing our knowledge of tissue development and repair, processes that find their most direct applications in regenerative medicine.

“One day we will be able to re-build damaged organs and keep the whole body fit and healthy. But right now we must strengthen our knowledge of how tissues are built and how they are maintained,” say James Sharpe, Head of EMBL Barcelona, and Marco Milán, coordinator of the Cell and Developmental Biology programme.

Researchers at IRB Barcelona discover a crucial gene involved in the development of the placenta

The work is the first to report on the key role of the TLK2 gene in mouse embryo development.

The study solidifies an important role for both TLK1 and TLK2 in genome stability.

A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.

The Drosophila fly brings to light the role of morphogens in limb growth

Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster.

Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process.

Understanding the development of limbs in Drosophila paves the way to research into congenital defects in vertebrates.

M. Milán: “To study how cells communicate with each other, perhaps the best model organism is the fruit fly”

The “Meet Our Scientists” video entitled “Our relative the fly” presents the research performed by Marco Millán on the fruit fly.

He studies the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, its proper functioning and the formation of a tumour.

The fly reveals a new signal involved in limb growth

Researchers at IRB Barcelona identify a fundamental role of the JAK/STAT signalling pathway in the development and growth regulation of limbs in Drosophila.

Published in Nature Communications, the study paves the way to research into the function of this pathway in vertebrate development and its possible involvement in human congenital diseases.