Results about: DNA

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease.

Key role identified for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials

Big Data analysis identifies new cancer risk genes

Researchers at the Centre for Genomic Regulation (CRG) in collaboration with IRB Barcelona, developed a new method to systematically identify genes contributing to heritable cancer risk.

The study, published in Nature Communications, is a success story for data sharing and openness in science.

Fran Supek: “Scientific research is like solving a Rubik's cube”

The video series Meet Our Scientists  presents Fran Supek, head of the Genome Data Science group at IRB Barcelona.

In the video “Solving the riddle of DNA”, Supek highlights the role played by the DNA spellchecker in repairing damage to the genome.