Results about: DNA repair
The recognition of many types of DNA lesions activates the cellular DNA damage response (DDR). The DDR orchestrates the appropriate cellular programs to maintain genome integrity after genotoxic stress.
The team headed by Núria López-Bigas has published an article in Cell about what might have favoured the periodicity of certain base pairs in the genomes of eukaryotic organisms.
The structure adopted by DNA when packaged inside cells influences the periodicity observed.
A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.
Fran Supek (IRB Barcelona) and Ben Lehner (CRG) identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors.
Many mutations in human cancers are caused by mistakes made by a repair mechanism or ‘DNA spellchecker’ rather than the actual damage to DNA caused by the environment.
Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.