Results about: drosophila

Two wings against cancer

In the conference Drosophila as a model in cancer”, to be held from 15 to 17 June in Barcelona, IRB Barcelona and the BBVA Foundation bring together a select group of leading scientists that use the fruit fly for cancer research.

This fly can be used to study specific types of tumour, ranging from leukaemia to brain tumours, and complex processes such as metastasis or the wasting syndrome (extreme muscle weakness) associated with cancer. In addition, Drosophila has proved to be an excellent tool for drug screening in vivo.

Nobert Perrimon is among the invited speakers. From his lab at Harvard, he has performed one of the largest screenings of molecules in flies in search of new anti-tumour applications of drugs that have already been approved by the FDA.

Special mention is also given to the participation of Sam Jackson, from the National Center for the Replacement, Refinement and Reduction of Animals in Research, a British organisation that promotes and supports the use of invertebrate models, such as Drosophila, for cancer research.

The fifth edition of the course for secondary school teachers starts at IRB Barcelona

The two-day workshop is part of the Teachers and Science programme, organised by the Catalunya-La Pedrera Foundation. This year’s programme will involve the participation of nine research centres from around Catalonia

The overall objective is to improve science teaching in order to increase scientific vocation among students

The IRB Barcelona workshop is dedicated to biomedical research with fruit flies

Discovery of an unexpected function of a protein linked to neurodegenerative diseases

A study done on fruit flies and published in Nature Communications reveals that the protein dDsk2, in addition to degrading proteins, also plays a key role in regulating gene expression.

This protein is also present in humans and is known to be mutated in several neurodegenerative diseases, including Alzheimer’s. But the mechanism by which these mutations contribute to the development of disease remains unclear.

IRB Barcelona is to start a study to examine the relationship between dDsk2 mutations and neurodegenerative diseases.

A mechanism that allows a differentiated cell to reactivate as a stem cell revealed

The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again.

Unveiling the genetic traits that favour the retention of stem cell properties is crucial for regenerative medicine.

Published in Cell Reports, the article is the fruit of collaboration between researchers at IRB Barcelona and CSIC.

Flies with colon cancer help to unravel the genetic keys to disease in humans

Researchers generate for the first time Drosophila melanogaster with intestinal cancer and reveal key genetic factors behind human colon cancer.

The scientists identify a human gene that favours the proliferation of tumour cells in early stages of colon cancer.

Furthermore, the flies are useful for faster and more economic drug screening.