Results about: enzymes

Our research focuses on three angles of peptide and protein chemistry: the design, synthesis and structure of bioactive molecules. From a structural perspective, we apply modern NMR techniques to study complex molecular recognition processes.

Key role identified for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials