Results about: genetic code

Our research addresses the evolution of the protein synthesis machinery, the molecular interactions that regulate it, and the biomedical applications that can be derived from its study. Our research projects are focused around the biology of transfer RNA (tRNA).

The “DNA corrector” is more efficient in the most important regions of the genome

A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.

Lluís Ribas: "We look for answers about the origin and evolution of life"

"In love with the genetic code", the new video in the series Meet Our Scientists, presents the research performed by Lluís Ribas on the genetic code and protein synthesis, both of which are essential for life.

Ribas highlights the impact of the evolution of the enzyme ADAT, described in  the journal Cell in 2012. The appearance of ADAT was decisive for the separation of species into the three domains of life, and it could be of biomedical and biotech relevance.

Discovery of a fundamental limit to the evolution of the genetic code

A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.

The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.

The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.

The discovery could have applications in synthetic biology.