Results about: genomic instability
The recognition of many types of DNA lesions activates the cellular DNA damage response (DDR). The DDR orchestrates the appropriate cellular programs to maintain genome integrity after genotoxic stress.
The work is the first to report on the key role of the TLK2 gene in mouse embryo development.
The study solidifies an important role for both TLK1 and TLK2 in genome stability.
A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.
As of November, Núria López-Bigas, winner of the 2016 Banco Sabadell Foundation Prize for Biomedical Research, will join IRB Barcelona to continue her research on cancer using computational biology.
The Institute has also recruited Croatian scientist Fran Supek, who will launch his laboratory in 2017.
Scientists shed light on how cells with an incorrect number of chromosomes lead to tumour development
Aneuploid cells—that is to say those with an abnormal number of chromosomes—are found in most human tumours.
A study conducted at IRB Barcelona on the fly Drosophila reveals how surviving aneuploid cells favour tumour development.