Results about: heteromeric amino acid transporters
One of the functions of the kidney is the tubular re-absorption of solutes, such as amino acids, filtrated in the glomerulus. Several amino acid transporters are involved in this process and when defective they cause primary inherited aminoacidurias (PIA).
Researchers at IRB Barcelona, BSC, and the University of Bern observe the first structure of a human HAT at low resolution.
HAT amino acid transporters are involved in pathologies such as aminoacidurias, cancer, viral infections and cocaine addiction.
The breakthrough published in the Proceedings of the National Academy of Science USA allows researchers to delve into the functions of HATs and to address the rational drug design of inhibitors.
The study has been partially funded by the European project EDICT (European Drug Initiative on Channels and Transporters), devoted to increasing the number of membrane protein structures available.