Results about: histones

Key role identified for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials

BigH1—the key histone for male fertility

Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.

The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.

Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.

Histone 1, the guardian of genome stability

Genomic instability is the main risk factor for tumour development in humans. Therefore understanding its origin and exploring therapeutic targets is paramount.

Histone 1 silences a region of the genome that causes irreparable DNA damage when translated and is lethal for the organism.

Understanding the molecular origin of epigenetic markers

Researchers at IRB Barcelona discover the molecular mechanism that determines how epigenetic markers influence gene expression

And in the beginning was histone 1

A team at IRB Barcelona identifies an essential protein for embryonic viability during the first cell divisions in the fly Drosophila.

This protein, called dBigH1, which is a variant of histone 1, could also be associated with fertility issues.