Results about: Horizon 2020

Advances made to combat cancer relapse

Modesto Orozco’s lab has published a paper in Chemical Communications about a therapeutic tool to prevent treatment resistance in breast cancer.

The tool has been tested in tumour cells in vitro and will now need to be tested in animal models before moving on to the development of a valid treatment for patients.

Genomics prepares to jump to three dimensions

Specialists advance toward the “Google Earth” of the genome, which will allow them to see the detailed structure of DNA folded within the nucleus, from atomic resolution to the level of the entire molecule

3D genomics promises to reveal the hidden layer of gene regulation and allow researchers to uncover the causes of many diseases

20 world leaders in 3D genomics will meet today until Wednesday in Barcelona at the Barcelona BioMed Conference organized by IRB Barcelona and the BBVA Foundation.

Getting ready to celebrate European science

The first ENABLE Scientific Symposium “Breaking Down Complexity: Innovative Models and Techniques in Biomedicine”, is gearing up to welcome more than 250 young researchers to Barcelona from 15 to 17 November. The Symposium is mainly organised by and for PhD students and Postdocs from four international institutes, including IRB Barcelona. Covering a wide range of topics, from synthetic biology to translational medicine, the event will involve eight high-profile invited speakers, 16 short talks and 100 posters presented by attendees, and will offer opportunities for career development and outreach initiatives.

A new tool to enter the era of multiscale genomics and dynamic chromatin

Scientists in the Multiscale Complex Genomics (MuG) Consortium are working on new cloud-based computational infrastructure to support and improve the existing genome analysis tools. The beta-version of the Virtual Research Environment (VRE) was presented for the first time in Cambridge in April. MuG is a Horizon 2020 project coordinated by IRB Barcelona Group Leader Modesto Orozco.

“If you want to be successful in obtaining a grant, broaden your portfolio when you are a PhD student”

How can young scientists obtain funding to continue their research as postdocs? IRB Barcelona’s Research and Academic Administration Department is here to help them. In the most recent workshop they organised, “How to be successful in your postdoctoral fellowship application”, held on 12 July, in vivo approached the Irish chemist Eimer Tuite, Senior Lecturer in Biophysical Chemistry at Newcastle University (UK), and evaluator of Marie Skłodowska-Curie actions (MSCA) to learn some tricks that might be useful for young researchers interested in applying for one of these grants.

IRB Barcelona goes full on open access

Open access is the future of scientific publications. The EU's H2020 funding and the 2011 Spanish Science Law require scientists to make their research freely available. In May, the Institute signed an agreement with the University of Barcelona that gives IRB Barcelona access to their repository. Ignasi Labastida, a physicist by training, works at the Learning and Research Resources Centre (CRAI) at the UB and is in charge of the University's open access activities. He explains the importance of the repository, and what to do to make sure researchers' scientific production is freely accessible.

“ENABLE is an exciting challenge for young researchers”

One of the faces behind EU Horizon 2020’s ENABLE (European Academy for Biomedical Science) project is that of Clara Caminal, Head of the Academic & International Scientific Affairs Office. She sees the coordination of this European project as “a great success” for the Institute and “a significant achievement” in her career. She is convinced that taking part in the organisation of scientific conferences, the focus of ENABLE, will be “a tremendous experience” for young researchers. “It'll be an opportunity for them to gain valuable experience in organising an international symposium with European partners,” she adds.

Europe injects 3 million euros into three-dimensional genomics

IRB Barcelona is to coordinate a Horizon2020 bioinformatics project that seeks to lay the groundwork for the emerging field of 3D genomics.

3D genomics provides information about the structures adopted by folded DNA inside a cell and about how they change over time and in response to alterations in cell environment. Modesto Orozco, the coordinator of the project says, “The 3D perspective will allow us to better relate changes in the genome with the corresponding diseases, because although 1D information is relevant, it falls short.”

Over three years, the project aims to provide a set of methods and integrated databases that can be used to store and process the data deriving from studies devoted to 3D genomics.

The European consortium comprises six international leading centres in method development and visualisation in 3D genomics.