Results about: hypermutation
The mechanism unveiled triggers a mutation fog, causing hundreds of mutations in each tumor, which spread through the genome of lung, head-and-neck and breast cancers.
Researchers from the Genome Data Science Lab have identified the antiviral APOBEC3A enzyme as the major cause of this new type of hypermutation.
Published in Nature Genetics, the study shows how the mutation fog process generates many oncogenic “cancer driver” mutations, thus accelerating tumour development.
Part of the European Research Council’s reasoning for providing their coveted Starting Grants is to “provide top talent with good conditions at the right time to thrive.” For the team led by Fran Supek (b. Zagreb, Croatia, 1981), the right time has just arrived with the award of a Starting Grant worth 1.5 million euros of funding. His project, called HYPER-INSIGHT, was among the 13% of successful proposals of the 3,085 applications made to the 2017 ‘Starting Grants’ Call.
ERC Starting Grants support young talented researchers over 5 years.
The IRB Barcelona group leader will focus on the genomes of hypermutated tumours to detect cancer vulnerabilities.