Results about: metastasis
Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries.
The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:
Intricate signalling networks control cell division, differentiation, movement, organization and death. Understanding how cells read and transform these signals into changes in cell behaviour is a major research focus of our group.
Colorectal cancer (CRC) is the most frequent and the second-most deadly type of cancer with around 700,000 deaths worldwide.
The mechanism unveiled triggers a mutation fog, causing hundreds of mutations in each tumor, which spread through the genome of lung, head-and-neck and breast cancers.
Researchers from the Genome Data Science Lab have identified the antiviral APOBEC3A enzyme as the major cause of this new type of hypermutation.
Published in Nature Genetics, the study shows how the mutation fog process generates many oncogenic “cancer driver” mutations, thus accelerating tumour development.
Scientists at IRB Barcelona determine the genetic alterations in the cells of cancer patients caused by the main cancer therapies.
This is an important step towards understanding the long-term side effects and optimizing treatments against cancer.
The results have been published in the journal Nature Genetics.