Results about: mRNA translation
Recent years have seen a paradigm shift in our understanding of gene activity and regulation. It is now clear that processing of primary transcripts as well as translational control open a myriad of opportunities for gene regulation, which are extensively used in virtually every human gene.
Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.
These findings will help researchers to better understand pathological processes such as cancer.
• ICREA professor Raúl Méndez publishes a study in Nature describing how the CPBE1 protein “takes the brakes off” the production of proteins associated with the cell switch from being healthy to tumorous.
• The study highlights CPEB proteins as promising targets, thus opening up a new and unexplored therapeutic window.
• The lab has developed a system for screening compounds that impede the action of CPEB proteins in tumors.