Results about: mRNA translation

Recent years have seen a paradigm shift in our understanding of gene activity and regulation. It is now clear that processing of primary transcripts as well as translational control open a myriad of opportunities for gene regulation, which are extensively used in virtually every human gene.

Towards a deeper understanding of genome regulation

Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.

These findings will help researchers to better understand pathological processes such as cancer. 

Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development

• ICREA professor Raúl Méndez publishes a study in Nature describing how the CPBE1 protein “takes the brakes off” the production of proteins associated with the cell switch from being healthy to tumorous.

• The study highlights CPEB proteins as promising targets, thus opening up a new and unexplored therapeutic window.

• The lab has developed a system for screening compounds that impede the action of CPEB proteins in tumors.