Results about: peptides

Our research focuses on three angles of peptide and protein chemistry: the design, synthesis and structure of bioactive molecules. From a structural perspective, we apply modern NMR techniques to study complex molecular recognition processes.

Chiral molecules are those that are not superimposable on their mirror image. Consequently, there can be two distinct isomers of these molecules, called enantiomers. Many of the compounds associated with living organisms are chiral, for example proteins, enzymes, DNA, hormones, etc.

Scorpion venom to shuttle drugs into the brain

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain. 

The barrier, which protects the brain, prevents drugs used for the treatment of neurological diseases and brain tumours from entering the organ.

Researchers develop a new class of covalent inhibitor for a protein involved in brain diseases

For the scientific community, the protein POP (prolyl oligopeptidase) is an attractive therapeutic target for the treatment of cognitive and neurodegenerative disorders.

Scientists at IRB Barcelona have developed the first POP inhibitors that are irreversible, selective and brain-permeable.

Promising compounds against a cancer target

The molecules synthesized by Ernest Giralt’s lab at IRB Barcelona bind a key protein in cancer that has received little attention as a therapeutic target.

The long-term goal is to provide a new chemotherapy treatment.