Results about: protein complex
Researchers identify the component that allows a lethal type of bacteria to spread resistance to antibiotics
Scientists at IRB Barcelona identify a key component of the machinery that allows Staphylococcus aureus to transfer genes that confer antibiotic resistance.
Infection by antibiotic-resistant S. aureus is a serious threat in hospitals worldwide.
Halting the spread of antibiotic-resistant bacteria is one of the strategies available to tackle hospital infections.
Ground-breaking research sometimes arises as a result of coincidence, multidisciplinarity and, of course, perseverance. Biochemist Oriol Gallego (Barcelona, 1978) is a Ramón y Cajal Research Associate in Raúl Méndez’s Translational Control of Cell Cycle and Differentiation Lab. Oriol led a promising study that has just been published in Cell. Combining genetic engineering, super-resolution microscopy, and biocomputation, he was able to see a 3D “protein nanomachine” in a living yeast cell. This breakthrough paves the way for inspiring future discoveries, such as the live observation of how viruses use protein complexes to infect cells.
Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3D the protein machinery inside living cells
Published in the journal Cell, the study unveils key functional features of an assembly of proteins that is vital for animals and plants.
With this new strategy in hand, it will be possible to study cellular protein machinery in health and in disease.