Results about: protein dynamics
A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease.
A study at IRB Barcelona sheds light on the dynamics of protein aggregates that behave like “droplets of oil in water” and that are described as membraneless cytoplasmic organelles.
These organelles regulate protein activity during cell division.
This is the first study at the Institute to address the so-called liquid-like droplets, which are attracting the attention of researchers worldwide.
Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.
They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.
The European Research Council provides funding until 2020 through a Consolidator Grant given to Xavier Salvatella, biophysicist at IRB Barcelona.
It is known that signalling occurs within proteins; however, how these signals are transmitted remains unclear, and it is a question that could transform the field of drug discovery.
The project will focus on the target protein for the treatment of prostate cancer.