Results about: protein synthesis
Our research addresses the evolution of the protein synthesis machinery, the molecular interactions that regulate it, and the biomedical applications that can be derived from its study. Our research projects are focused around the biology of transfer RNA (tRNA).
A study reveals that the essential protein SLIMP coordinates protein synthesis and DNA replication in mitochondria
The team headed by ICREA researcher, Lluís Ribas, has published a study in Cell Report describing a functional network that coordinates protein synthesis and DNA replication in animal mitochondria.
These findings contribute to our understanding of the mechanisms involved in mitochondrial dysregulation associated with diseases such as MELAS and MERRF and may help to identify new therapeutic approaches.
Back from a very rewarding stay in Yale, Pol already has new ideas in mind to overcome the barrier that protects the brain and makes it so difficult to design drugs to cure neurological diseases.
"In love with the genetic code", the new video in the series Meet Our Scientists, presents the research performed by Lluís Ribas on the genetic code and protein synthesis, both of which are essential for life.
Ribas highlights the impact of the evolution of the enzyme ADAT, described in the journal Cell in 2012. The appearance of ADAT was decisive for the separation of species into the three domains of life, and it could be of biomedical and biotech relevance.
A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.
The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.
The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.
The discovery could have applications in synthetic biology.