Results about: relapse
Colorectal Cancer (CRC) is one of the leading causes of death by cancer worldwide. Most colorectal tumors develop as benign lesions but a small proportion progress to more malignant stages when the appropriate alterations in oncogenes and tumour suppressor genes occur.
A study published in Nature Genetics by researchers at IRB Barcelona explains the basis for the classification of colon tumours in good or bad prognosis by analysing the tissue surrounding the tumour cells.
The scientists are currently developing a test that enables the identification of patients at risk of relapse after surgical removal of the tumour by measuring 4-6 genes expressed by the tumour microenvironment.
The researchers also propose to test in patients a particular drug that blocks the metastatic capacity of colorectal cancers in mice.
This drug has been tested using novel technology that allows the growth of mini colon cancers, also known as organoids, derived from patient samples.