Results about: skin

Skin ages when the main cells in the dermis lose their identity and function

A study in mice done at IRB Barcelona and CNAG-CRG explains that dermal fibroblasts lose their cell identify over time and with it their capacity to produce and secrete collagen and other proteins.

"We want to offer a new perspective on the internal body clock,” says Guiomar Solanas

How does the circadian clock change when we get older? This is the question that has driven research associate Guiomar Solanas and “la Caixa” PhD student Francisca Oliveira Peixoto, both at IRB Barcelona, to study the daily pattern of gene activity. The answer, as laid out in two studies headed by Salvador Aznar Benitah and published in the journal Cell, rejects the widely held belief that stem cells lose their circadian rhythm with age. The studies demonstrate that the daily pattern of gene activity is not lost with age but is rather reprogrammed for new functions and that a low calorie diet delays alterations in the rhythm of stem cells.