Results about: Smad proteins

Inter- and intra-cellular communication is fundamental for the survival of multi-cellular organisms, and defects in this process are often key features of many diseases. At the molecular level, the basis for information transfer is the formation of complex networks of interacting components.

Researchers discover a mechanism that inhibits the Smad signalling pathway

  • A group of scientists headed by Maria Macias, ICREA researcher at IRB Barcelona, describes the mechanism through which TGIF1 inhibits the activity of Smad proteins.
  • The study, which used molecular and structural biology techniques to analyse this interaction, has been published in Nucleic Acids.

Understanding the adaptability of Smads

A study published in Nature Communications and led by Maria J Macias highlight new DNA motifs for the Smads proteins.

Maria Macias: “Structural biologists are as meticulous as watchmakers”

The third video of IRB Barcelona’s series “Meet Our Scientists” is devoted to ICREA researcher Maria Macias, who describes her field as “exciting and understandable”.

Her research focuses on determining protein structures that have the potential to improve drug development