Results about: SMAD2

Scientists decipher the keys underlying the differences between SMAD2 and SMAD3, two almost identical transcription factors but with distinct roles

Both transcription factors regulate the expression of genes involved in embryo development, among other functions, although they exert very different roles.

The study also refutes the theory accepted to date that SMAD2 does not bind to DNA.

Published in Genes & Development, the research is the result of collaboration between Maria J. Macias’ lab at IRB Barcelona and Joan Massagué’s group at the Sloan Kettering Institute (New York, US).