Results about: therapeutic targets
The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism
Published in Nature, the study indicates that a defect in CPEB4 could be the link between environmental factors that alter brain development and the genes that determine susceptibility to autism
ICREA researcher Roger Gomis, head of the Growth Control and Cancer Metastasis Lab, has recently been awarded a 2016 "Knowledge Industry Grant" (Producte), by the Catalan Government’s Agency for Management of University and Research Grants, for the further development of a therapy for the treatment of breast cancer. His 18-month project, "Lipid targeting in breast cancer", aims to obtain a monoclonal antibody, based on a well-defined molecular target, that is suitable for patient treatment and to complete its pre-clinical development phase.
The labs headed by Angel R. Nebreda, Ernest Giralt and Roger Gomis secure funding for further development of three medical applications.
The three projects will receive 220,000 euros from the "Knowledge Industry" programme, which is run by the Catalan Government and cofunded by ERDFs.
p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions.
Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors.
These findings are the result of combining fundamental biological data using computational techniques.
The finding paves the way for the identification of new therapeutic targets for many diseases.