Results about: TLK1

Key role identified for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials

Researchers at IRB Barcelona discover a crucial gene involved in the development of the placenta

The work is the first to report on the key role of the TLK2 gene in mouse embryo development.

The study solidifies an important role for both TLK1 and TLK2 in genome stability.

A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.