Results about: transcriptional regulation

The loss of protein Dnmt3a increases the number of carcinogen-induced squamous tumours

Researchers led by Salvador Aznar-Benitah at IRB Barcelona investigate the role of Dnmt3a and Dnmt3b proteins in skin homeostasis and tumour development in adult mice.

The study has been published in eLife and deserved an eLife digest aimed at a more general audience.

Scientists in Barcelona discover a potential treatment for cirrhosis

A study by IRB Barcelona and IDIBAPS reveals a therapeutic target to prevent the development of the many abnormal blood vessels that cause gastrointestinal bleeding—the main complication in cirrhosis.

Cirrhosis is the main risk factor for liver cancer. The same target may be the key to preventing and treating this condition.

Cirrhosis figures among the top twenty causes of death from disease worldwide.

Scientists unveil a molecular mechanism that controls plant growth and development

Researchers at IRB and IBMB-CSIC, in Barcelona, and at the University of Wageningen, in the Netherlands, reveal how auxin hormone-regulated proteins activate developmental genes in plants.

Auxins are key components of plant growth and have many applications in agriculture. The biomedical application of these hormones are also being addressed.

The study is published this week in the scientific journal Cell.

IRB Barcelona researchers discover mechanism that regulates steroid hormone production in Drosophila

• The study, published in Current Biology, links growth to sexual maturity.

• Scientists at IRB Barcelona identify a micro-RNA key to insulin’s regulation of steroid hormones in flies.