Results about: tRNA
Our research addresses the evolution of the protein synthesis machinery, the molecular interactions that regulate it, and the biomedical applications that can be derived from its study. Our research projects are focused around the biology of transfer RNA (tRNA).
Eva Novoa was one of the first students to complete a PhD in as part of the ”la Caixa”/IRB Barcelona International PhD Programme in Biomedicine. She was a PhD student at IRB Barcelona between 2008 and 2012. Six months ago, she moved to Sydney, Australia to join the Garvan Institute of Medical Research as a Senior Research Officer. She just received the Young Research Award from the Catalan Society for Biology.
A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.
The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.
The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.
The discovery could have applications in synthetic biology.
Researchers at IRB Barcelona identify a family of efficient and selective molecules to combat the parasite Plasmodium, causal agent of malaria.
Two analogues of borrelidin were found to cure 100% of infected mice and produce immunological memory in these animals, a property not previously observed in an antimalarial drug.
Growing resistance to current treatment for malaria increases the need for new drug candidates.