Results about: tumour microenvironment
Colorectal Cancer (CRC) is one of the leading causes of death by cancer worldwide. Most colorectal tumors develop as benign lesions but a small proportion progress to more malignant stages when the appropriate alterations in oncogenes and tumour suppressor genes occur.
Researchers at IRB Barcelona reveal the capacity of epithelial-derived tumours to grow in the absence of a microenvironment.
Featured on the cover of the journal Proceedings of the National Academic of Sciences (PNAS), the study identifies the cell types and molecular mechanism involved in tumour initiation and growth.
The results of this study contribute to our understanding of the internal mechanisms of the tumour, which may provide a therapeutic target.
Researchers at IRB Barcelona unravel a role for tumour suppressor genes in restricting the growth of neighbouring cell populations.
The study, published yesterday in PLoS Biology, might have implications for understanding the early events of tumorigenesis and the selection of the tumour-initiating cells.