Results about: UV light
Fran Supek (IRB Barcelona) and Ben Lehner (CRG) identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors.
Many mutations in human cancers are caused by mistakes made by a repair mechanism or ‘DNA spellchecker’ rather than the actual damage to DNA caused by the environment.
Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.
Researchers led by Salvador Aznar-Benitah at IRB Barcelona investigate the role of Dnmt3a and Dnmt3b proteins in skin homeostasis and tumour development in adult mice.
The study has been published in eLife and deserved an eLife digest aimed at a more general audience.