PhD News

<p>A invasive front of highly aggressive tumour cells (in green). Confocal microscopy image. Alexandra Avgustinova, IRB Barcelona.</p>
19 Nov 2018

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.

Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.

<p>Skin of a young mouse. The image shows a cross section of the skin with the fibroblasts indicated in green. The thickness of the dermis and the density of fibroblasts is much greater in young skin than in aged skin– cell nuclei, in blue (M Salzer, IRB Bar</p>
8 Nov 2018

A study in mice done at IRB Barcelona and CNAG-CRG explains that dermal fibroblasts lose their cell identify over time and with it their capacity to produce and secrete collagen and other proteins.

<p>Roger Gomis, head of the Growth Control and Cancer Metastasis Lab</p>
2 Nov 2018

The Spanish Association of Cancer Research recognizes his work and grants him the ASEICA Young Investigator Award 2018.

The award ceremony will be held in Valencia on 6, 7 and 8 November.

<p>Ernest Giralt receives the diploma at La Marató ceremony</p>
2 Nov 2018

The project presented by Ernest Giralt (IRB Barcelona) and Jordi Vila (ISGLOBAL) has been awarded € 260,000.

Of the 214 projects that applied for funding, 36 were selected on the basis of the evaluation of 103 scientists.

This is the third time that the IRB Barcelona researcher has received funding from “La Marató”.

<p>The DNA molecule, formed by a double helix, winds around histone molecules twice, thus forming nucleosomes. The pink regions indicate those enriched in Adenine/Thymine base pairs (Author: Iris Joval Granollers)</p>
1 Nov 2018

The team headed by Núria López-Bigas has published an article in Cell about what might have favoured the periodicity of certain base pairs in the genomes of eukaryotic organisms.

The structure adopted by DNA when packaged inside cells influences the periodicity observed.

25 Oct 2018

On Monday 22 October, the Dolors Aleu Hall registered a full house,  with more than 170 people gathering to celebrate the long and successful career of Joan J. Guinovart. Authorities, current and former members of the Board of Trustees, scientific collaborators, family members, representatives from philanthropic institutions, members of IRB Barcelona, and former students accompanied the founder and former director of the institute during 13 years on this special occasion. Indeed, due to interest in the event, it was retransmitted by video streaming in an annex hall. In total, more than 200 people rendered tribute to a life dedicated to biochemistry and science outreach.

At 18:00...

<p>Joan Massagué. Source: SINC</p>
30 Sep 2018

SINC has published an interview with Joan Massagué, president of the Scientific Committee at IRB Barcelona and director of the Sloan Kettering Institute in New York, in which he comments on metastasis: "Most are annihilated by the immune system, but others mock the defenses, they manage to nest and over time they can grow. That's the metastasis: it's an exception, something that did not have to happen. Metastasis is like a criminal. That in a society there is delinquency does not mean that all people are delinquents ".

Link to Agencia SINC

<p>TLK inhibition leads to replication stress (green) and extensive DNA damage (red) in cultured cancer cells. Sandra Segura-Bayona, IRB Barcelona.</p>
8 Aug 2018

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials

<p>Miquel Duran-Frigola, Associate Researcher at the Structural Bioinformatics and Network Biology lab, IRB Barcelona</p>
31 Jul 2018

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH.

The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

<p>The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells. (Guillem Garaulet and Francisca Mulero, CNIO)</p>
26 Jul 2018

A team headed by Manuel Serrano at IRB Barcelona has designed a drug encapsulation system that selectively targets senescent cells.

The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.