Work headed by scientist Antonio Zorzano proposes a possible therapeutic target to treat fatty liver, a disease for which there is currently no treatment.
The study, which was done in collaboration with the Pere Virgili Institute, has been published in the journal Cell.
The antibody mAb806 is used to treat glioblastoma, although its mechanism of action has been unknown until now.
The study, published in the journal PNAS, paves the way to extend treatment with mAb806 to more types of tumours and to the development of more personalised therapies.
Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis.
A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments.
Through the campaign called #MetastasisChallenge, the centre aims to raise €5 M over the next four years.
Metastasis is responsible for 90% of deaths from cancer, and this campaign aims to rally social support for research in order to speed up discoveries.
The Eldiario.es portal has published an article on the "100tífiques" initiative, led by the Catalan Foundation for Research and Innovation, the Department of Education of the Generalitat de Catalunya, the Barcelona Education Consortium, and the Barcelona Institute of Science and Technology (BIST), of which IRB Barcelona forms part. In the article, they quoted Muriel Arimon, Public Engagement and Science Education Officer of the centre, who upholds that "we can all do science".
Link to Eldiario.es
The breakthrough made by researchers at IRB Barcelona allows the study of the role of each molecular component in the stability and conformation of DNA crystals.
The new molecular simulation techniques are expected to reduce the time and cost of obtaining crystals in the laboratory.
The IRB Barcelona scientist received the award during the opening ceremony of the academic year of this institution.
Cope, ABC, La Rioja, among other media, have published an article about the inscriptions to the IV Women's Race for Research from Asociación Española Contra el Cáncer (AECC). The resources obtained from this race will be used to finance two predoctoral grants at two institutions in La Rioja. Also, the project "Research on the impact of senescence influenced by inflammation as a therapy on cancer stem cells" led by Marta Kovatcheva, researcher at IRB Barcelona, will be financed.
Link to Cope...
The web Hidden Nature has published an article about the 10 investigations that they considered to be the most important ones published in 2018. One of them refers to epigenetic therapies and mentions research research that supports and rejects them. In this regard, they mention the study led by Salvador Aznar Benitah at IRB Barcelona and published in Nature Cell Biology. The study in question concludes that care must be taken with drugs that inhibit epigenetic factors as they could cause the appearance of aggressive tumours.
Link to Hidden Nature
A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.
Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.