A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.
Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.
A study in mice done at IRB Barcelona and CNAG-CRG explains that dermal fibroblasts lose their cell identify over time and with it their capacity to produce and secrete collagen and other proteins.
The Spanish Association of Cancer Research recognizes his work and grants him the ASEICA Young Investigator Award 2018.
The award ceremony will be held in Valencia on 6, 7 and 8 November.
The project presented by Ernest Giralt (IRB Barcelona) and Jordi Vila (ISGLOBAL) has been awarded € 260,000.
Of the 214 projects that applied for funding, 36 were selected on the basis of the evaluation of 103 scientists.
This is the third time that the IRB Barcelona researcher has received funding from “La Marató”.
The team headed by Núria López-Bigas has published an article in Cell about what might have favoured the periodicity of certain base pairs in the genomes of eukaryotic organisms.
The structure adopted by DNA when packaged inside cells influences the periodicity observed.
On Monday 22 October, the Dolors Aleu Hall registered a full house, with more than 170 people gathering to celebrate the long and successful career of Joan J. Guinovart. Authorities, current and former members of the Board of Trustees, scientific collaborators, family members, representatives from philanthropic institutions, members of IRB Barcelona, and former students accompanied the founder and former director of the institute during 13 years on this special occasion. Indeed, due to interest in the event, it was retransmitted by video streaming in an annex hall. In total, more than 200 people rendered tribute to a life dedicated to biochemistry and science outreach.
SINC has published an interview with Joan Massagué, president of the Scientific Committee at IRB Barcelona and director of the Sloan Kettering Institute in New York, in which he comments on metastasis: "Most are annihilated by the immune system, but others mock the defenses, they manage to nest and over time they can grow. That's the metastasis: it's an exception, something that did not have to happen. Metastasis is like a criminal. That in a society there is delinquency does not mean that all people are delinquents ".
Link to Agencia SINC
Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.
Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.
Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials
A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH.
The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.
A team headed by Manuel Serrano at IRB Barcelona has designed a drug encapsulation system that selectively targets senescent cells.
The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.