Travis Stracker

    <p>Stracker</p>
    Research Group: 
    Genomic Instability and Cancer Laboratory
    Unit: 
    CANCER SCIENCE
    Position: 
    Group Leader
    Office: 
    EM01B43-44
    Telephone: 
    +34 93 40 31183
    Email: 
    travis.stracker@irbbarcelona.org

     

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    Travis Stracker is principal investigator in the Oncology program at the Institute for Research in Biomedicine. He was previously a Research Associate in the laboratory of John Petrini in the Molecular Biology department at the Sloan-Kettering Institute for Cancer Research in New York.

    1996 B.S. Genetics at the University of Georgia, Athens, GA. 1997-2002 Ph.D. in Biology in the lab of Matthew Weitzman at the Salk Institute for Biological Studies and the University of California, San Diego. 2003-2009 Research Associate in the lab of John Petrini at the Sloan-Kettering Institute for Cancer Research, New York.

    Travis Stracker’s research has focused on the functions of the DNA damage response in many aspects of chromosome metabolism and tumor suppression. During his doctoral work, Travis characterized Adenovirus proteins that target the Mre11 complex for degradation, providing insight into the interactions between DNA viruses and the cellular damage response. In the lab of John Petrini, Travis has investigated genetic interactions of the Mre11 complex with other damage response proteins and their influence on genome stability and tumorigenesis. These studies revealed new insights into damage signaling and the role of the damage response in tumor suppression. Travis was a Leukemia and Lymphoma Society Special Fellow and a Ramón y Cajal researcher.

    Meet our scientists Videos

    Travis Stracker: “Mantener la estabilidad del genoma”

    Selected group publications

    Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1, MCIDAS or CCNO deficient mice
    Terré B, Lewis M, Gil-Gómez G, Han Z, Hao L, Aguilera M, Prats N, Roy S, Zhao H and Stracker TH.
    Development, (2019)
    EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy
    Stracker TH.
    Mol Cell Oncol, 5 (3), e1445943 (2018)
    Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors
    Lee SB, Segura-Bayona S, Villamor-Payà M, Saredi G, Todd MAM, Attolini CS, Chang TY, Stracker TH and Groth A.
    Sci Adv, 4 (8), eaat4985 (2018)
    CCNO mutations in NPH?
    Núnez-Ollé M, Stracker TH and Gil-Gómez G.
    Aging-us, 10 (2), 158-159 (2018)
    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
    Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH and Nebreda AR.
    Cancer Cell, 33 (6), 1094-1110. (2018)
    Molecular basis of Tousled-Like Kinase 2 activation
    Mortuza GB, Hermida D, Pedersen AK, Segura-Bayona S, López-Méndez B, Redondo P, Rüther P, Pozdnyakova I, Garrote AM, Muñoz IG, Villamor-Payà M, Jauset C, Olsen JV, Stracker TH and Montoya G.
    Nat Commun, 9 (1), 2535 (2018)
    EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation
    Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O and Stracker TH.
    Nat Cell Biol, 20 (2), 162-174 (2018)
    GEMC1 is a critical regulator of multiciliated cell differentiation
    Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V and Stracker TH.
    Embo J, 35 (9), 942-60 (2016)
    NBS1 is required for macrophage homeostasis and functional activity in mice
    Pereira-Lopes S, Tur J, Calatayud-Subias JA, Lloberas J, Stracker TH and Celada A.
    Blood, (2015)
    EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele
    Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM and Stracker TH.
    Nucleic Acids Res, 43 (15), 7371-87 (2015)
    CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination
    Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J and Stracker TH.
    Nat Commun, 6 7676 (2015)
    Systematic identification of molecular links between core and candidate genes in breast cancer
    Arroyo R, Suñé G, Zanzoni A, Duran-Frigola M, Alcalde V, Stracker TH, Soler-López M and Aloy P.
    J Mol Biol, 427 (6 Pt B), 1436-50 (2015)
    ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
    Chen WT, Ebelt ND, Stracker TH, Xhemalce B, Van Den Berg CL and Miller KM.
    Elife, 4 (2015)
    Regulation of USP28 deubiquitinating activity by SUMO conjugation
    Zhen Y, Knobel PA, Stracker TH and Reverter D.
    J Biol Chem, 289 (50), 34838-50 (2014)
    The MRE11 complex: an important source of stress relief
    Rein K and Stracker TH.
    Exp Cell Res, 329 (1), 162-9 (2014)
    A-to-I editing on tRNAs: biochemical, biological and evolutionary implications
    Torres AG, Piñeyro D, Filonava L, Stracker TH, Batlle E and Ribas de Pouplana L.
    Febs Lett, 588 (23), 4279-86 (2014)
    USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism
    Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP and Stracker TH.
    Mol Cell Biol, 34 (11), 2062-74 (2014)
    PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication
    Bianchi J, Rudd SG, Jozwiakowski SK, Bailey LJ, Soura V, Taylor E, Stevanovic I, Green AJ, Stracker TH, Lindsay HD and Doherty AJ.
    Mol Cell, 52 (4), 566-73 (2013)
    The ATM signaling network in development and disease
    Stracker TH, Roig I, Knobel PA and Marjanović M.
    Front Genet, 4 37 (2013)
    Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression
    Foster SS, De S, Johnson LK, Petrini JH and Stracker TH.
    P Natl Acad Sci Usa, 109 (25), 9953-8 (2012)
    Full publication list