Results about: cancer

Recent years have seen a paradigm shift in our understanding of gene activity and regulation. It is now clear that processing of primary transcripts as well as translational control open a myriad of opportunities for gene regulation, which are extensively used in virtually every human gene.

<p>Angel R Nebreda</p>

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:


The recognition of many types of DNA lesions activates the cellular DNA damage response (DDR). The DDR orchestrates the appropriate cellular programs to maintain genome integrity after genotoxic stress.

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease.


Candidates with a strong interest in the microtubule cytoskeleton who would like to join our group should e-mail a cover letter with CV including contact information for references to

Our research focuses on three angles of peptide and protein chemistry: the design, synthesis and structure of bioactive molecules. From a structural perspective, we apply modern NMR techniques to study complex molecular recognition processes.

Investigadores del IRB Barcelona analizan cómo las alteraciones en el sistema de degradación de proteínas actúan en la generación de tumores

La investigación publicada en la revista Nature Cancer analiza cómo las células tumorales contienen alteraciones genéticas que impiden la correcta degradación de las proteínas involucradas en la aparición y evolución de tumores, dando lugar a un comportamiento celular aberrante.

Para el estudio se ha desarrollado un modelo de inteligencia artificial que ha permitido obtener la más extensa anotación del sistema de degradación de proteínas mediado por ubiquitina.

El análisis propone una posible nueva vía de intervención clínica en cáncer a través de la inhibición de oncoproteínas con un comportamiento aberrante en su sistema de degradación.