The Origins and the Biological Consequences of the Pur/Pyr DNA•RNA Asymmetry
Terrazas M, et al. Chem (2019) DOI: 10.1016/j.chempr.2019.04.00
Brain tumours reset their clocks
Solanas G & Benitah SA Nature (2019) DOI: 10.1038/d41586-019-03042-0
Cellular Senescence: Defining a Path Forward
Gorgoulis V, et al. Cell (2019) DOI: 10.1016/j.cell.2019.10.005
Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
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Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments
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Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben M & Gabaldon T. Nature Microbiology (2019) DOI: 10.1038/s41564-019-0552-0
From poor prognosis to promising treatment
Tauriello DVF Science (2019) DOI: 10.1126/science.aaw3609
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh B, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-11594-y
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren E, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-09837-z
Modeling, Simulations, and Bioinformatics at the Service of RNA Structure
Dans PD, et al. Chem (2019) DOI: 10.1016/j.chempr.2018.09.015
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana L, et al. PNAS (2019) DOI: 10.1073/pnas.1821442116
Pergola-web: a web server for the visualization and analysis of longitudinal behavioral data using repurposed genomics tools and standards
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Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics
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Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock
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Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
Batlle R, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-10946-y
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo A, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-09923-2
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo A, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-11705-9
The chemistry of senescence
Lozano-Torres B, et al. Nature Reviews Chemistry (2019) DOI: 10.1038/s41570-019-0108-0
The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
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Atomic structure of the Epstein-Barr virus portal
Machon C, et al. Nature Communications (2019) DOI: 10.1038/s41467-019-11706-8
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
Welz P.-S, et al. Cell (2019) DOI: 10.1016/j.cell.2019.05.009
Asymmetric base-pair opening drives helicase unwinding dynamics
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An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic A, et al. Chem (2019) DOI: 10.1016/j.chempr.2018.12.007
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
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A Third Shot at EGFR: New Opportunities in Cancer Therapy
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Regulation of death receptor signaling by the autophagy protein TP53INP2
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The static and dynamic structural heterogeneities of B-DNA: extending Calladine-Dickerson rules
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Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning
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Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond
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The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle
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Transforming Growth Factor-β Signaling in Immunity and Cancer
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Brain tumours reset their clocks
Solanas, G, et al. Nature (2019) DOI: 10.1038/d41586-019-03042-0
Survival skills ensure that cancer spreads
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The mutational footprints of cancer therapies
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The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
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Local Determinants of the Mutational Landscape of the Human Genome
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BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
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Defining the Independence of the Liver Circadian Clock
Koronowski KB et al. Cell (2019) DOI: 10.1016/j.cell.2019.04.025
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
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Reduced mutation rate in exons due to differential mismatch repair
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Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas G, et al. Cell. 2017 Aug 10; 170(4):678-692.e20.

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Background photo: Skin cancer stem cells to study biological processes related to different types of cancer and metastasis. Lorenzo Rinaldi, Alumni.