We highlight our participation in the "PanCancer" consortium which has resulted in several excellent publications in 2020. Including 4 articles in Nature and others in high impact journals.

Hog1 activation delays mitotic exit via phosphorylation of Net1
Silvia Tognetti (...) Eulàlia de Nadal & Francesc Posas. PNAS DOI: 10.1073/pnas.1918308117
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Jessica Vitos-Faleato (...) & Angel R. Nebreda. PNAS DOI: 10.1073/pnas.1921404117
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio L, (…) & Milán M. Developmental Cell. DOI: 10.1016/j.devcel.2020.01.017
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Lidia Mateo (...) & Patrick Aloy. Genome Medicine DOI: 10.1186/s13073-020-00774-x
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Sentís I (...) & Lopez-Bigas N. Genome Biology. DOI: 10.1186/s13059-020-02192-z
Tagu D. Selection following gene duplication shapes recent genome evolution in the pea aphid acyrthosiphon pisum
Fernandez R (...) & Gabaldon T. Molecular Biology and Evolution. DOI: 10.1093/molbev/msaa110
MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life
Chorostecki U (...) & Gabaldón T. Nucleic Acids Research. DOI:10.1093/nar/gkaa282
A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress
Cristina Viéitez (...) Francesc Posas & Eulàlia de Nadal. Nucleic Acids Research. DOI: 10.1093/nar/gkaa081
A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level
Walther J, (…) & Orozco M. Nucleic Acids Research. DOI: 10.1093/nar/gkaa015
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó P., (…) & Azorín F. Nucleic Acids Research. DOI: 10.1093/nar/gkaa122
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Alexandros A. (...) & Toni Gabaldón. Nature Communications. DOI: 10.1038/s41467-020-17705-4.
Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
Sonia Ciudad (...) & Natàlia Carulla. Nature Communications DOI:10.1038/s41467-020-16566-1
Timing the origin of eukaryotic cellular complexity with ancient duplications
Julian Vosseberg, (...) Toni Gabaldón & Berend Snel. Nature Ecology & Evolution DOI: 10.1038/s41559-020-01320-z
Catalytic Regioselective Isomerization of 2,2‐Disubstituted Oxetanes to Homoallylic Alcohols
Cabré(...) & Antoni Riera. Angewandte Chemie. DOI: 10.1002/anie.201915772
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Fabian Zimmermann (...) & Jens Luders. Science Advances DOI: 10.1126/sciadv.abe0894
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Marina Salvadores, (...) & Fran Supek. Science Advances. DOI: 10.1126/sciadv.aba1862
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast càncer
Pascual R, (...) & Méndez R. Science Advances. DOI: 10.1126/sciadv.aax3868
Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
Luis Martínez-Crespo, (...) & Manuel Palacín, P. Ballester. Chem. DOI: 10.1016/j.chempr.2020.08.018
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Cian J. Lynch (...) & Manuel Serrano. Nature Cell Biology. DOI: 10.1038/s41556-020-0573-1
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral C, (…) & Batlle E. Cell Stem Cell. DOI: 10.1016/j.stem.2020.04.012
P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis
Albert Cabré, Antoni Riera & Xavier Verdaguer. Accounts of Chemical Research. DOI: 10.1021/acs.accounts.9b00633
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
David Mas-Ponte & Fran Supek. Nature Genetics. DOI: 10.1038/s41588-020-0674-6
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola M, (...) & Aloy P. Nature Biotechnology DOI:10.1038/s41587-020-0502-7
A compendium of mutational cancer driver genes
Francisco Martínez-Jiménez (...) & Nuria Lopez-Bigas. Nature Reviews Cancer

Thank you!

We would like to thank all those who contributed to our achievements in 2020.
Our hope is to bring biomedical advances to society.
Our goal, to improve people’s quality of life.