We highlight our participation in the "PanCancer" consortium which has resulted in several excellent publications in 2020. Including 4 articles in Nature and others in high impact journals.
Hog1 activation delays mitotic exit via phosphorylation of Net1
Silvia Tognetti (...) Eulàlia de Nadal & Francesc Posas. PNAS DOI: 10.1073/pnas.1918308117
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Jessica Vitos-Faleato (...) & Angel R. Nebreda. PNAS DOI: 10.1073/pnas.1921404117
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio L, (…) & Milán M. Developmental Cell. DOI: 10.1016/j.devcel.2020.01.017
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Lidia Mateo (...) & Patrick Aloy. Genome Medicine DOI: 10.1186/s13073-020-00774-x
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Sentís I (...) & Lopez-Bigas N. Genome Biology. DOI: 10.1186/s13059-020-02192-z
Tagu D. Selection following gene duplication shapes recent genome evolution in the pea aphid acyrthosiphon pisum
Fernandez R (...) & Gabaldon T. Molecular Biology and Evolution. DOI: 10.1093/molbev/msaa110
MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life
Chorostecki U (...) & Gabaldón T. Nucleic Acids Research. DOI:10.1093/nar/gkaa282
A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress
Cristina Viéitez (...) Francesc Posas & Eulàlia de Nadal. Nucleic Acids Research. DOI: 10.1093/nar/gkaa081
A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level
Walther J, (…) & Orozco M. Nucleic Acids Research. DOI: 10.1093/nar/gkaa015
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó P., (…) & Azorín F. Nucleic Acids Research. DOI: 10.1093/nar/gkaa122
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Alexandros A. (...) & Toni Gabaldón. Nature Communications. DOI: 10.1038/s41467-020-17705-4.
Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
Sonia Ciudad (...) & Natàlia Carulla. Nature Communications DOI:10.1038/s41467-020-16566-1
Timing the origin of eukaryotic cellular complexity with ancient duplications
Julian Vosseberg, (...) Toni Gabaldón & Berend Snel. Nature Ecology & Evolution DOI: 10.1038/s41559-020-01320-z
Catalytic Regioselective Isomerization of 2,2‐Disubstituted Oxetanes to Homoallylic Alcohols
Cabré(...) & Antoni Riera. Angewandte Chemie. DOI: 10.1002/anie.201915772
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Fabian Zimmermann (...) & Jens Luders. Science Advances DOI: 10.1126/sciadv.abe0894
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Marina Salvadores, (...) & Fran Supek. Science Advances. DOI: 10.1126/sciadv.aba1862
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast càncer
Pascual R, (...) & Méndez R. Science Advances. DOI: 10.1126/sciadv.aax3868
Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
Luis Martínez-Crespo, (...) & Manuel Palacín, P. Ballester. Chem. DOI: 10.1016/j.chempr.2020.08.018
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Cian J. Lynch (...) & Manuel Serrano. Nature Cell Biology. DOI: 10.1038/s41556-020-0573-1
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral C, (…) & Batlle E. Cell Stem Cell. DOI: 10.1016/j.stem.2020.04.012
P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis
Albert Cabré, Antoni Riera & Xavier Verdaguer. Accounts of Chemical Research. DOI: 10.1021/acs.accounts.9b00633
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
David Mas-Ponte & Fran Supek. Nature Genetics. DOI: 10.1038/s41588-020-0674-6
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola M, (...) & Aloy P. Nature Biotechnology DOI:10.1038/s41587-020-0502-7
A compendium of mutational cancer driver genes
Francisco Martínez-Jiménez (...) & Nuria Lopez-Bigas. Nature Reviews Cancer