Published in Science
Led by Dr. Direna Alonso-Curbelo at IRB Barcelona and partners at the Sloan Kettering Institute, the study published in the journal Science has unveiled how the expansion of cell-to-cell communication plays a crucial role in the early stages of pancreatic cancer development. Utilizing advanced genetic mouse models and computational analysis, the team has mapped early cellular changes, suggesting pathways for early detection and intervention.
The research has pinpointed the significance of increased cellular plasticity and the improved ability of pre-cancerous cells to communicate, as central to cancer progression. By pioneering novel computational methods to dissect cell interactions, the findings reveal that these cellular dialogues are organised and critical to cancer development.
For more information:
https://www.irbbarcelona.org/en/news/scientific/expansion-cell-cell-communication-drives-early-development-pancreatic-cancer-new
