Selected Publications

Brain-muscle communication prevents muscle aging by maintaining daily physiology.

Kumar A*, Vaca-Depere M, Mortimer T, (...), Benitah SA*, Muñoz-Cánoves P*

Science, 384, 563-572 (2024)

DOI: 10.1126/science.adj8533

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Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Toledano I, Supek F*, Lehner Ben*

Nature Genetics, 56, 914–1924 (2024)

DOI: 10.1038/s41588-024-01878-5

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Five latent factors underlie response to immunotherapy

Usset J, Rosendahl Huber A, Andrianova MA, Batlle E, Carles J, (…); Tabernero J, Vivancos A, Muiños F, Gonzalez-Perez A*, Lopez-Bigas N*

Nature Genetics, 56, 2112–2120 (2024) 

DOI: 10.1038/s41588-024-01899-0

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Identification of clonal hematopoiesis driver mutations through in silico saturation mutagenesis.

Demajo S; Ramis-Zaldivar JE, Muiños F, Grau ML, Andrianova M, López-Bigas N*, González-Pérez A*.

Cancer Discovery, 4, 1717-1731 (2024)

DOI: 10.1158/2159-8290.CD-23-1416

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Origins of second malignancies in children and mutational footprint of chemotherapy in normal tissues

Sánchez-Guixé M, Muiños F, Pinheiro-Santin M, González-Huici V, Rodriguez-Hernandez CJ, Avgustinova A, Lavarino C, González-Pérez A, Mora J, López-Bigas, N*

Cancer Discovery, 14, 1-12 (2024) 

DOI: 10.1158/2159-8290.CD-23-1186

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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers.

Salvadores M, Supek F*

Nature Cancer, 5, 2 (2024)

DOI: 10.1038/s43018-023-00707-8

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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib S, López-Domínguez JA*, Lalinde-Gutiérrez M, Prats N, Marin I, Boix O, García-Garijo A, Meyer K, Muñoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, (…); Serrano M*

Nature Cancer, 5, 448-462 (2024)

DOI: 10.1038/s43018-023-00712-x

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Recent gene selection and drug resistance underscore clinical adaptation across Candida species

Schikora-Tamarit, MA; Gabaldón, T*

Nature Microbiology, 9, 284-307 (2024)

DOI: 10.1038/s41564-023-01547-z

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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis.

Mortimer T*, Zinna V, (...), Welz PS*, Muñoz-Cánovas P*, Benitah SA*

Cell Stem Cell, 834–849 (2024)

DOI:  10.1016/j.stem.2024.04.013

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The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization

Puerto M, Shukla M, Bujosa P, Pérez-Roldán J, Torràs-Llort M, Tamirisa S, Carbonell A, Solé C, Puspo JA, Cummings CT, de Nadal E, Posas F, Azorín F*, Rowley MJ*.

Nucleic Acids Research, 52, 5596-5609 (2024)

DOI: 10.1093/nar/gkae198

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CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes

Farre-Gil D, Arcon JP, Laughton CA, Orozco M*.

Nucleic Acids Research, 52, 6791-6801(2024)

DOI: 10.1093/nar/gkae444

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Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation.

Mas-Ponte D, Supek F*

Nucleic Acids Research, 52, 4393-4408 (2024)

DOI: 10.1093/nar/gkae252

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An integrated machine-learning model to predict nucleosome architecture

Sala A, Labrador M, Buitrago D, De Jorge P*, Battistini F, Brun-Heath I, Orozco M*

Nucleic Acids Research, 52, 10132-10143 (2024)

DOI: 10.1093/nar/gkae689

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Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.

Barbosa BMG, (...), Riera A*, Mayor-Ruiz C* 

Angewandte Chemie (International Ed. Print), 63, e202316730 (2024)

DOI: 10.1002/anie.202316730

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Cyclometallated Imides as Templates for the H‐Bond Directed Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Methyl, N‐Alkyl and N‐Aryl Imines

Wen  Y, Fernández‐Sabaté M, Lledós A, Sciortino G, Eills J, Marco‐Rius I, Riera A*, Verdaguer X*.

Angewandte Chemie, 63, 26, e202404955 (2024)

DOI: 10.1002/anie.202404955

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Mucosal TLR5 activation controls healthspan and longevity

Lim JS, Jeon EJ, Go HS, Kim HJ, Kim KY, Nguyen TQT, Lee DY, Kim KS, Pietrocola F, (…), Lee CH*, Rhee JH*, Serrano M*, Cho KA*.

Nature Communications, 15, 46 (2024)

DOI: 10.1038/s41467-023-44263-2

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Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

Besedina E, Supek F*

Nature Communications, 15, 1 (2024)

DOI: 10.1038/s41467-024-50552-1

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Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

López-Polo V, Maus M, Zacharioudakis E, Lafarga M, Stephan-Otto Attolini C, Marques FDM, Kovatcheva M, Gavathiotis E, Serrano M*

Nature Communications, 15, 1 (2024)

DOI: 10.1038/s41467-024-51363-0

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Comprehensive detection and characterization of human druggable pockets through binding site descriptors

Comajuncosa-Creus A, Jorba G, Barril X, Aloy P*.

Nature Communications, 15, 7917 (2024)

DOI: 10.1038/s41467-024-52146-3

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Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter

Rullo-Tubau J, Martinez-Molledo M, Bartoccioni P, Puch-Giner I, Arias A, Saen-Oon S, Stephan-Otto Attolini C, Artuch R, Diaz L, Guallar Victor, Errasti-Murugarren E, Palacin M*, Llorca O*

Nature Communications, 15, 1, 2986 (2024)

DOI: 10.1038/s41467-024-47385-3

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