Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells.

Cañellas-Socias A (...) Batlle E.

Nature, 611, 603 – 613 (2022) DOI: 10.1038/s41586-022-05402-9

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.

Herpers B (…) Batlle E* Throsby M*

Nature Cancer, 3 (4), 418 - 436 (2022) DOI: 10.1038/s43018-022-00359-0

Mutational signatures are markers of drug sensitivity of cancer cells.

Levatić J (...) Supek F.

Nature Communications, 13(1), 2926 (2022) DOI: 10.1038/s41467-022-30582-3

Cellular senescence is immunogenic and promotes anti-tumor immunity.

Oriol Pich (...) Abel Gonzalez-Perez & Nuria Lopez-Bigas

Nature Communications (2021) DOI: 10.1038/s41467-021-24858-3

Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

Irazoki A (...) Zorzano A*, Sebastián D*.

Aging Cell, 4:e13583 (2022) DOI: 10.1111/acel.13583

MiOS an integrated imaging and computational strategy to model gene folding with nucleosome resolution.

Neguembor MV (...) Orozco M, Dans PD, Cosma MP

Nature Structural & Molecular Biology, 29 (10) 1011-1023 (2022) DOI: 10.1038/s41594-022-00839-y

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque.

Fernández-Torras A (...) Aloy P.

Nature Communications, 13, 1, 5304 (2022) DOI: 10.1038/s41467-022-33026-0

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy.

Alvarez-Varela A, (…), Sancho E, Attolini CSO, Batlle E

Nature Cancer, 3 (9), 1052 - 1070 (2022) DOI: 10.1038/s43018-022-00402-0

Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation.

Bernués J(...) Azorín F.

Nucleic Acids Research, 50(16):9212-9225 (2022) DOI: 10.1093/nar/gkac716

DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors.

Barissi S (...) Orozco M.

Nucleic Acids Research, 50 (16) 9105 – 9114 (2022) DOI: 10.1093/nar/gkac708

PhylomeDB V5: an expanding repository for genome-wide catalogues of annotated gene phylogenies.

Fuentes D (...) Gabaldón T.

Nucleic Acids Research, 50 (D1), D1062-D1068 (2022) DOI: 10.1093/nar/gkab966

Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation.

Duran-Arqué B (...) Mendez R

Genome Biology, 23, 1, 92 (2022) DOI: 10.1186/s13059-022-02759-y

PerSVade: personalized structural variant detection in any species of interest.

Schikora-Tamarit MA, Gabaldón T.

Genome Biology, 23 (1), 175 (2022) DOI: 10.1186/s13059-022-02737-4

Discovering the drivers of clonal hematopoiesis.

Pich O (...) Lopez-Bigas N.

Nature Communications,13 (1), 4267 (2022) DOI: 10.1038/s41467-022-31878-0

A single WNT enhancer drives specification and regeneration of the Drosophila wing.

Gracia-Latorre E (...) Milán M.

Nature Communications,13 (1) 4794 – 4794 (2022) DOI: 10.1038/s41467-022-32400-2

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening.

Alvarez MM (...) Supek F.

Nature Communications,13 (1), 4520 (2022) DOI: 10.1038/s41467-022-32285-1

The impact of rare germline variants on human somatic mutation processes.

Vali-Pour M (...) Supek F.

Nature Communications, 13 (1), 3724 (2022) DOI: 10.1038/s41467-022-31483-1

Iridium-Catalyzed Asymmetric Hydrogenation of 23-Diarylallyl Amines with a Threonine-Derived P-Stereogenic Ligand for the Synthesis of Tetrahydroquinolines and Tetrahydroisoquinolines.

Rojo P (...) Riera A, Verdaguer X

Angewandte Chemie (International Ed. Print), 61 (29): e202204300 DOI: 10.1002/anie.202204300

The central clock suffices to drive the majority of circulatory metabolic rhythms.

Petrus P (...) Benitah SA

Science Advances, 8, 26 eabo2896 (2022) DOI: 10.1126/sciadv.abo2896

Thank you!

We would like to thank all the people and institutions who have made 2022 an exceptional year. Thanks to your contributions, our science is bringing about biomedical breakthroughs that have an increasing impact on people's lives. We would also like to thank all the people and organisations who have joined the Metastasis Challenge.

Every donation, every event, every legacy helps us get one step closer to our goal of stopping metastasis.