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Nature, 611, 603 – 613 (2022) DOI: 10.1038/s41586-022-05402-9

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.

Herpers B (…) Batlle E* Throsby M*

Nature Cancer, 3 (4), 418 - 436 (2022) DOI: 10.1038/s43018-022-00359-0

Mutational signatures are markers of drug sensitivity of cancer cells.

Levatić J (...) Supek F.

Nature Communications, 13(1), 2926 (2022) DOI: 10.1038/s41467-022-30582-3

Cellular senescence is immunogenic and promotes anti-tumor immunity.

Oriol Pich (...) Abel Gonzalez-Perez & Nuria Lopez-Bigas

Nature Communications (2021) DOI: 10.1038/s41467-021-24858-3

Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

Irazoki A (...) Zorzano A*, Sebastián D*.

Aging Cell, 4:e13583 (2022) DOI: 10.1111/acel.13583

MiOS an integrated imaging and computational strategy to model gene folding with nucleosome resolution.

Neguembor MV (...) Orozco M, Dans PD, Cosma MP

Nature Structural & Molecular Biology, 29 (10) 1011-1023 (2022) DOI: 10.1038/s41594-022-00839-y

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque.

Fernández-Torras A (...) Aloy P.

Nature Communications, 13, 1, 5304 (2022) DOI: 10.1038/s41467-022-33026-0

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy.

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Nature Cancer, 3 (9), 1052 - 1070 (2022) DOI: 10.1038/s43018-022-00402-0

Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation.

Bernués J(...) Azorín F.

Nucleic Acids Research, 50(16):9212-9225 (2022) DOI: 10.1093/nar/gkac716

DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors.

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Nucleic Acids Research, 50 (16) 9105 – 9114 (2022) DOI: 10.1093/nar/gkac708

PhylomeDB V5: an expanding repository for genome-wide catalogues of annotated gene phylogenies.

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Nucleic Acids Research, 50 (D1), D1062-D1068 (2022) DOI: 10.1093/nar/gkab966

Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation.

Duran-Arqué B (...) Mendez R

Genome Biology, 23, 1, 92 (2022) DOI: 10.1186/s13059-022-02759-y

PerSVade: personalized structural variant detection in any species of interest.

Schikora-Tamarit MA, Gabaldón T.

Genome Biology, 23 (1), 175 (2022) DOI: 10.1186/s13059-022-02737-4

Discovering the drivers of clonal hematopoiesis.

Pich O (...) Lopez-Bigas N.

Nature Communications,13 (1), 4267 (2022) DOI: 10.1038/s41467-022-31878-0

A single WNT enhancer drives specification and regeneration of the Drosophila wing.

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Nature Communications,13 (1) 4794 – 4794 (2022) DOI: 10.1038/s41467-022-32400-2

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening.

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Nature Communications,13 (1), 4520 (2022) DOI: 10.1038/s41467-022-32285-1

The impact of rare germline variants on human somatic mutation processes.

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Nature Communications, 13 (1), 3724 (2022) DOI: 10.1038/s41467-022-31483-1

Iridium-Catalyzed Asymmetric Hydrogenation of 23-Diarylallyl Amines with a Threonine-Derived P-Stereogenic Ligand for the Synthesis of Tetrahydroquinolines and Tetrahydroisoquinolines.

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Angewandte Chemie (International Ed. Print), 61 (29): e202204300 DOI: 10.1002/anie.202204300

The central clock suffices to drive the majority of circulatory metabolic rhythms.

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Science Advances, 8, 26 eabo2896 (2022) DOI: 10.1126/sciadv.abo2896


Queremos dar las gracias a las personas e instituciones que han hecho del 2022 un año excepcional. Gracias a sus aportaciones, nuestra ciencia está generando avances que tienen un impacto creciente en la vida de las personas. También queremos dar las gracias a todas las personas y organizaciones que se han sumado al Reto Metástasis.

Cada donación, cada evento, cada legado, nos ayuda a acercarnos un paso más a nuestro objetivo de frenar la metástasis.