All our cells have membranes that separate the cell content from the external environment. Thirty percent of human proteins exert their action in these and other cell membranes.
Technology can now extend the album of 3D “photos” of membrane proteins, which currently covers 3% of these molecules
Science Week comes to IRB Barcelona
Researchers at IRB Barcelona discover that the liver and brain communicate in order to regulate appetite
Secondary school teachers get up to date with cancer research at IRB Barcelona
This year the Institute for Research in Biomedicine (IRB Barcelona) is once again participating in Science Week in Catalonia (
The liver stores excess glucose, sugar, in the form of glycogen—chains of glucose—, which is later released to cover body energy requirements.
On Friday 7 and Saturday 8 November, 15 teachers from secondary schools in Catalonia will have the opportunity to get up to date with the latest research in cancer, metastasis and personalized medi
Extensive article published in Sunday’s issue of ARA on the research line developed by Meritxell Teixidó in Ernest Giralt’s lab to extract natural poison from bees, scorpions and spiders, which provides peptides able to cross the blood-brain barrier. Many drugs cannot enter the brain because of this barrier, which serves to protect this organ against infections.
Coverage in the media of the 25th Barcelona BioMed Conference on membrane proteins—molecules that account for 30% of the human genome. To date, the atomic structures of only 3% of these proteins are known from an estimated 15,000.
The newspaper El Correo, edited in Vizcaya, publishes a whole-page article on the link between the brain and the liver with respect to appetite control.
The study, which was performed in the "Metabolic engineering and diabetes therapy” lab, headed by Joan J. Guinovart, has been widely echoed in the media.
Felice Alessio Bava
ex PhD student in the Translational Control of Cell Cycle and Differentiation Lab
«We suspected that CPEB1, a protein involved in regulating mRNA translation in the cytoplasm, might also be active in the nucleus and play a role in controlling pre-mRNA processing. We discovered that it affects the alternative generation in the mature mRNA of the 3'-UTR, regions where most of the elements regulating translation in time and space are located.»
More info about this news here.
«Controlling a biological process from outside is the future of chemistry and opens up promising roads for advancements in pharmacological research.»
More info on this news here.
«Our study highlights the complexity of p38 functions, both in cancer and in the maintenance of normal tissues. It shows why an inhibitor of this molecule could effectively have undesirable side effects. But these do not exclude it from being a target against cancer.»
More on this news here.
«98% of the potential therapeutic molecules against diseases of the central nervous system cannot cross the blood-brain barrier. We develop peptides with the capacity to open the doors of the barrier and act as shuttles when attached to a therapeutic molecule.»
Quick facts about IRB
IRB Barcelona is home to nearly 450 research, technical and support staff from 35 countries who share the common goal of contributing to the advancement of the biomedical sciences through investigator–driven research, and improving quality of life by applying advances in this field.
The convergence of biology, chemistry, and structural and computational biology is unique at IRB Barcelona and opens a strategic window to gain insight into basic molecular processes in health and disease.
Research is conducted by 23 groups organized into 5 interdisciplinary programmes. Each programme includes a diverse faculty of researchers with overlapping scientific interests. The research areas have been structured to be highly interactive, fostering multidisciplinarity by combining modern molecular biology, classical genetics, biochemistry, structural biology, bioinformatics, systems biology, advanced microscopy, and genomic and proteomic approaches.
IRB Barcelona is housed within the Barcelona Science Park on the University of Barcelona Pedralbes Campus. It is an integral part of the ‘Bioregion of Catalonia’, a rich landscape of research centres of excellence, universities, science parks, hospitals, scientific infrastructures and pharmaceutical companies, all with a focus on the life sciences. It is a member of the CERCA network of government research centres.