Scientific News

<p>Breast tumours have high levels of LIPG expression (F Slebe, IRB Barcelona)</p>
5 Apr 2016

In an article published in Nature Communications, scientists at IRB Barcelona reveal that breast cancer cells require fatty acids from the extracellular environment in order to continue proliferating.

<p>Microscopic structure of mouse testicle tissue (P.Mikolcevic, IRB Barcelona)</p>
30 Mar 2016

Scientists at IRB Barcelona discover a crucial protein for meiosis—the cell division process that gives rise to sex cells.

Without the RingoA protein, both male and female mice are sterile.

Published in Nature Communications, the results could pave the way for the development of male contraceptives.

<p>Drosophila trachea fragment. Externally, there is no difference between the Tr2 segment, where facultative stem cells are found, and Tr3, which indicates the rest of the cells in the tissue.  (N.J. Djabrayan, IRBBarcelona)</p>
11 Mar 2016

Scientists at IRB Barcelona and CSIC reveal that the combination of two molecular signals determines which cells that have already differentiated can regain their stem cell properties.

Their studies on fruit flies allow for advancements in the field of regenerative medicine and a better understanding of processes involved in cancer.

<p>GEMC1 is required for the generation of multiciliated cells. Images of mouse tracheas. The cilia (yellow) are clearly evident in the wild-type mice and absent in mice with no GEMC1. (Berta Terré, IRB Barcelona)</p>
2 Mar 2016

IRB Barcelona identifies GEMC1 as a master gene for the generation of multiciliated cells—cells with fine filaments that move fluids and substances—which are found exclusively in the brain, respiratory tract, and reproductive system.

Defects in multiciliated cells lead to ciliopathies—rare and complex diseases that are poorly understood and for which not all causative genes have been identified.

<p>Image of the larval tracheal main tube, stained in white to mark the chitinous ECM and in red to mark the cell-cell junctions</p>
22 Feb 2016

Researchers at IRB Barcelona and CSIC discover a mechanism through which the cells of an organism interact with their extracellular matrix
 

<p>In the picture, precursor cells of fly wing tissue, labelled for various proteins. This fly model has been used to perform experiments addressing the relationship between chromosome instability, aneuploidy, and tumorigenesis (Lara Barrio, IRB Barcelona)</p>
9 Feb 2016

Aneuploid cells—that is to say those with an abnormal number of chromosomes—are found in most human tumours.

A study conducted at IRB Barcelona on the fly Drosophila reveals how surviving aneuploid cells favour tumour development.

<p>The compound Cp28 (orange) binds to the EGF protein (green), a target in cancer. This interaction prevents EGF from binding to its receptor EGFR.</p>
3 Feb 2016

The molecules synthesized by Ernest Giralt’s lab at IRB Barcelona bind a key protein in cancer that has received little attention as a therapeutic target.

The long-term goal is to provide a new chemotherapy treatment.

<p>Tissue sample from healthy human liver (IRBBarcelona/IDIBAPS)</p>
11 Dec 2015

A study by IRB Barcelona and IDIBAPS reveals a therapeutic target to prevent the development of the many abnormal blood vessels that cause gastrointestinal bleeding—the main complication in cirrhosis.

Cirrhosis is the main risk factor for liver cancer. The same target may be the key to preventing and treating this condition.

Cirrhosis figures among the top twenty causes of death from disease worldwide.

10 Dec 2015

A comment by Cayetano González in Nature News & Views

<p>Plasmid DNA simulation (P Dans. IRB Barcelona)</p>
17 Nov 2015

The simulation method developed in Modesto Orozco’s laboratory allows the study—with unprecedented accuracy—of structural changes in DNA and of the interaction of DNA with proteins and drugs.

All the simulations and posterior analyses are kept in the first online tool developed to date dedicated to atomic level simulations of nucleic acids.

The platform is free of charge and available to the entire scientific community through the Spanish Institute of Bioinformatics and the European network ELIXIR-Excellerate.

In addition to other uses, the new method provides greater insight into how DNA is recognised by proteins that modify its function or by the drugs that bind to it to exert their therapeutic action, thereby furthering our understanding of the biological function of DNA.