In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii
Vila-Farres X, Garcia de la Maria C, López-Rojas R, Pachón J, Giralt E and Vila J.
Clin Microbiol Infect, 4 (18), 383-7 (2012)

Recent patents of dipeptidyl peptidase IV inhibitors
Mendieta L, Tarrago T, Giralt E.
Expert Opin Ther Pat (21), 1693-1741 (2011)

Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010
López A, Tarragó T, Giralt E.
Expert Opin Ther Pat, 1-22 (2011)

Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.
Martínez J, Lisa S, Sánchez R, Kowalczyk W, Zurita E, Teixidó M, Giralt E, Andreu D, Avila J, Gasset M.
PLoS One (6), e27999 (2011)

15N relaxation NMR studies of prolyl oligopeptidase, an 80 kDa enzyme, reveal a pre-existing equilibrium between different conformational states.
Kichik N, Tarragó T, Claasen B, Gairí M, Millet O, Giralt E.
Chembiochem (12), 2737-2739 (2011)

Direct-reversible binding of small molecules to G protein βγ subunits.
Seneviratne AM, Burroughs M, Giralt E, Smrcka AV.
Biochim Biophys Acta (1814), 1210-1218 (2011)

On the role of flexibility in protein-ligand interactions: the example of p53 tetramerization domain.
Gordo S, Martos V, Vilaseca M, Menéndez M, Mendoza J, Giralt E.
Chem-asian J (6), 1463-1469 (2011)

Electrochemical investigation of cellular uptake of quantum dots decorated with a proline-rich cell penetrating peptide.
Marin S, Pujals S, Giralt E, Merkoci A.
Bioconjugate Chem (22), 180-185 (2011)

Rational design of a selective covalent modifier of G protein βγ subunits.
Dessal AL, Prades R, Giralt E, Smrcka AV
Mol Pharmacol (79), 24-33 (2011)

A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones
Cotrufo T, Pérez-Brangulí F, Muhaisen A, Ros O, Andrés R, Baeriswyl T, Fuschini G, Tarrago T, Pascual M, Ureña J, Blasi J, Giralt E, Stoeckli ET and Soriano E.
J Neurosci, 41 (31), 14463-80 (2011)

Molecular recognition at protein surface in solution and gas phase: Five VEGF peptidic ligands show inverse affinity when studied by NMR and CID-MS.
Dyachenko A, Goldflam M, Vilaseca M, Giralt, E.
Biopolymers (94), 689-700 (2010)

Improved Fmoc-based solid-phase synthesis of homologous peptide fragments of human and mouse prion proteins.
Grillo-Bosch D, Rabanal F, Giralt E.
J Pept Sci (17), 32-38 (2010)

Relevant elements of a maize γ-zein domain involved in protein body biogenesis
Llop-Tous I, Madurga S, Giralt E, Marzabal P, Torrent M, Ludevid MD,
J Biol Chem, 285, 35633-3564 (2010)

Molecular recognition at protein surface in solution and gas phase: Five VEGF peptidic ligands show inverse affinity when studied by NMR and CID-MS
Dyachenko A, Goldflam M, Vilaseca M and Giralt E.
Biopolymers, 6 (94), 689-700 (2010)

Towards the identification of unknown neuropeptide precursor-processing enzymes: Design and synthesis of a new family of dipeptidyl phosphonate activity probes for substrate-based protease identification
Sabidó E, Tarragó T and Giralt E.
Bioorgan Med Chem, 23 (18), 8350-5 (2010)

Fusion intermediates of HIV-1 gp41 as targets for antibody production: design, synthesis, and HR1-HR2 complex purification and characterization of generated antibodies
Mzoughi O, Gaston F, Granados GC, Lakhdar-Ghazal F, Giralt E and Bahraoui E.
Chemmedchem, 11 (5), 1907-18 (2010)

Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein
Hernáez B, Tarragó T, Giralt E, Escribano JM and Alonso C.
J Virol, 20 (84), 10792-801 (2010)

Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B
Mendieta L, Picó A, Tarragó T, Teixidó M, Castillo M, Rafecas L, Moyano A and Giralt E.
Chemmedchem, 9 (5), 1556-67 (2010)

Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers
Marques MR, Stüker C, Kichik N, Tarragó T, Giralt E, Morel AF and Dalcol II.
Fitoterapia, 6 (81), 552-6 (2010)

Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide
Guerrero S, Araya E, Fiedler JL, Arias JI, Adura C, Albericio F, Giralt E, Arias JL, Fernández MS and Kogan MJ.
Nanomedicine-uk, 6 (5), 897-913 (2010)

Simultaneous (19)F NMR screening of prolyl oligopeptidase and dipeptidyl peptidase IV inhibitors
Kichik N, Tarragó T and Giralt E.
Chembiochem, 8 (11), 1115-9 (2010)

N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles
Malakoutikhah M, Prades R, Teixidó M and Giralt E.
J Med Chem, 6 (53), 2354-63 (2010)

Folding and self-assembling with beta-oligomers based on (1R,2S)-2-aminocyclobutane-1-carboxylic acid
Torres E, Gorrea E, Burusco KK, Da Silva E, Nolis P, Rúa F, Boussert S, Díez-Pérez I, Dannenberg S, Izquierdo S, Giralt E, Jaime C, Branchadell V and Ortuño RM.
Org Biomol Chem, 3 (8), 564-75 (2010)

NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes
Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM and Giralt E.
Proc Natl Acad Sci U S A, 2 (10), 639-44 (2010)

A novel family of diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles
Teixidó M, Zurita E, Prades R, Tarrago T and Giralt E.
Adv Exp Med Biol (61), 227-8 (2009)

Use of the SPhos ligand to suppress racemization in arylpinacolboronate ester Suzuki couplings involving alpha-amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenylglycine, tyrosine, and tryptophan
Prieto M, Mayor S, Lloyd-Williams P and Giralt E.
J Org Chem, 23 (74), 9202-5 (2009)

A cost-effective labeling strategy for the NMR study of large proteins: selective 15N-labeling of the tryptophan side chains of prolyl oligopeptidase
Tarragó T, Claasen B, Kichik N, Rodriguez-Mias RA, Gairí M and Giralt E.
Chembiochem, 17 (10), 2736-9 (2009)

A new side opening on prolyl oligopeptidase revealed by electron microscopy
Tarragó T, Martín-Benito J, Sabidó E, Claasen B, Madurga S, Gairí M, Valpuesta JM and Giralt E.
Febs Lett, 20 (58), 3344-8 (2009)

An intramolecular O-N migration reaction on gold surfaces: toward the preparation of well-defined amyloid surfaces
Boussert S, Diez-Perez I, Kogan MJ, de Oliveira E and Giralt E.
Acs Nano, 10 (3), 3091-7 (2009)

Activity-based probes for monitoring postproline protease activity
Sabidó E, Tarragó T, Niessen S, Cravatt BF and Giralt E.
Chembiochem, 14 (10), 2361-6 (2009)

Retro-enantio N-methylated peptides as beta-amyloid aggregation inhibitors
Grillo-Bosch D, Carulla N, Cruz M, Sánchez L, Pujol-Pina R, Madurga S, Rabanal F and Giralt E.
Chemmedchem, 9 (4), 1488-94 (2009)

Using peptidyl aldehydes in activity-based proteomics
Sabidó E, Tarragó T and Giralt E.
Bioorg Med Chem Lett, 14 (19), 3752-5 (2009)

Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates
Comellas G, Kaczmarska Z, Tarragó T, Teixidó M and Giralt E.
PLoS One, 7 (4), e6222 (2009)

Homogeneous conjugation of peptides onto gold nanoparticles enhances macrophage response
Bastús NG, Sánchez-Tilló E, Pujals S, Farrera C, López C, Giralt E, Celada A, Lloberas J and Puntes. V
ACS Nano, 3 (6), 1335-44 (2009)

Cytosolic targeting of macromolecules using a pH-dependent fusogenic peptide in combination with cationic liposomes
Kobayashi S, Nakase I, Kawabata N, Yu HH, Pujals S, Imanishi M, Giralt E and Futaki S.
Bioconjugate Chem, 5 (20), 953-9 (2009)

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation
Carulla N, Zhou M, Arimon M, Gairí M, Giralt E, Robinson CV and Dobson CM.
Proc Natl Acad Sci U S A, 19 (10), 7828-33 (2009)

Shuttling gold nanoparticles into tumoral cells with an amphipathic proline-rich peptide
Pujals S, Bastús NG, Pereiro E, López-Iglesias C, Puntes VF, Kogan MJ and Giralt E.
Chembiochem, 6 (10), 1025-31 (2009)

Development and characterization of peptidic fusion inhibitors derived from HIV-1 gp41 with partial D-amino acid substitutions
Gaston F, Granados GC, Madurga S, Rabanal F, Lakhdar-Ghazal F, Giralt E and Bahraoui E.
Chemmedchem, 4 (4), 570-81 (2009)

Knitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy
Gordo S and Giralt E.
Protein Sci, 3 (18), 481-93 (2009)

Peptides conjugated to gold nanoparticles induce macrophage activation
Bastús NG, Sánchez-Tilló E, Pujals S, Farrera C, Kogan MJ, Giralt E, Celada A, Lloberas J and Puntes V
Mol Immunol, 46 (4), 743-48 (2009)

Novel system to achieve one-pot modification of cargo molecules with oligoarginine vectors for intracellular delivery
Takayama K, Tadokoro A, Pujals S, Nakase I, Giralt E and Futaki S.
Bioconjugate Chem, 2 (20), 249-57 (2009)

A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors
del Pozo-Rodríguez A, Pujals S, Delgado D, Solinís MA, Gascón AR, Giralt E and Pedraz JL.
J Control Release, 1 (13), 52-9 (2009)

Gold nanoparticles and microwave irradiation inhibit beta-amyloid amyloidogenesis
Araya E, Olmedo I, Bastus NG, Guerrero S, Puntes V, Giralt E and Kogan MJ
Nanoscale Research Letters, 11 (3), 435-43 (2008)

Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors
Tarragó T, Masdeu C, Gómez E, Isambert N, Lavilla R and Giralt E
ChemMedChem, 10 (3), 1558-65 (2008)

Perspectives on NMR in drug discovery: a technique comes of age
Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H and Siegal G
Nat Rev Drug Discov, 9 (7), 738-45 (2008)

Mechanism of binding of fluoroquinolones to the quinolone resistance-determining region of DNA gyrase: towards an understanding of the molecular basis of quinolone resistance
Madurga S, Sánchez-Céspedes J, Belda I, Vila J and Giralt E
Chembiochem, 13 (9), 2081-86 (2008)

Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor
Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M and Giralt E
Bioorg Med Chem, 5 (16), 7516-24 (2008)

Structure-activity relationship of kahalalide F synthetic analogues
Jiménez JC, López-Macià A, Gracia C, Varón S, Carrascal M, Caba JM, Royo M, Francesch AM, Cuevas C, Giralt E and Albericio F
J Med Chem, 16 (51), 4920-31 (2008)

Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries
Malakoutikhah M, Teixidó M and Giralt E
J Med Chem, 16 (51), 4881-89 (2008)

Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: a comparative study with epithelial cell cultures
Foerg C, Weller KM, Rechsteiner H, Nielsen HM, Fernández-Carneado J, Brunisholz R, Giralt E and Merkle HP
AAPS J, 2 (10), 349-59 (2008)

How changes in the sequence of the peptide CLPFFD-NH2 can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils
Olmedo I, Araya E, Sanz F, Medina E, Arbiol J, Toledo P, Alvarez-Lueje A, Giralt E and Kogan MJ
Bioconjug Chem, 6 (19), 1154-63 (2008)

Design and synthesis of FAJANU: a de novo C(2) symmetric cyclopeptide family
Garcia-Martin F, Cruz LJ, Rodriguez-Mias RA, Giralt E and Albericio F
J Med Chem, 11 (51), 3194-02 (2008)

Proline-rich, amphipathic cell-penetrating peptides
Pujals S and Giralt E
Adv Drug Deliv Rev, 39205 (60), 473-84 (2008)

The role of peptides in blood-brain barrier nanotechnology
Teixidó M and Giralt E
J Pept Sci, 2 (14), 163-73 (2008)

D-SAP: a new, noncytotoxic, and fully protease resistant cell-penetrating peptide
Pujals S, Fernández-Carneado J, Ludevid MD and Giralt E
ChemMedChem, 2 (3), 296-01 (2008)

Towards chemical chaperones: Rescue of p53 tetramerization by designed calyx[4]arene compounds
Gordo S, Martos V, Martinell M, Salvatella X, Gairí M, Menéndez M, de Mendoza J and Giralt E
Biopolymers, 4 (88), 621 (2007)

Gold nanoparticles for selective and remote heating of _ -amyloid protein aggregates
Bastus NG, Kogan M, Amigo R, Grillo-Bosch D, Araya E, Turiel A, Labarta A, Giralt E and Puntes VF
Materials Science and Engineering C, 39298 (27), 1236-40 (2007)

Does the solid-phase synthesis of a tetrapeptide represent a challenge at the onset of the XXI century? The case of cyclo(3R)-3-hydroxydecanoyl-L-seryl-(3R)-3-hydroxydecanoyl-L-seryl
Teixidó M, Caba JM, Prades R, Zurita E, Martinell M, Vilaseca M, Albericio F & Giralt E
Int J Pept Res Ther (13), 313-27 (2007)

Chemical synthesis of 19F-labeled HIV-1 protease using Fmoc-chemistry and ChemMatrix resin
Frutos S, Tulla-Puche J, Albericio F and Giralt E
Int J Pept Res Ther (13), 221-27 (2007)

Disruption of the HIV-1 protease dimer with interface peptides: Structural studies using NMR spectroscopy combined with [2-(13)C]-Trp selective labeling
Frutos S, Rodriguez-Mias RA, Madurga S, Collinet B, Reboud-Ravaux M, Ludevid D and Giralt E
Biopolymers, 2 (88), 164-73 (2007)

Structural analysis of substance P using molecular dynamics and NMR spectroscopy
Corcho FJ, Salvatella X, Canto J, Giralt E and Pérez JJ
J Pept Sci, 11 (13), 728-41 (2007)

Diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles
Teixidó M, Zurita E, Malakoutikhah M, Tarragó T and Giralt E.
J Am Chem Soc, 38 (129), 11802-13 (2007)

All-D proline-rich cell-penetrating peptides: a preliminary in vivo internalization study
Pujals S, Sabidó E, Tarragó T and Giralt E
Biochem Soc Trans (35), 794-96 (2007)

Self-assembly of a cyclobutane β -tetrapeptide to form nanosized structures
Rua F, Boussert S, Parella T, Diez-Perez I, Branchadell V, Giralt E and Ortuño RM
Org Lett, 18 (9), 3643-45 (2007)

Effect of the surface charge discretization on electric double layers. A Monte Carlo simulation study
Madurga S, Martín-Molina A, Vilaseca E, Mas F and Quesada-Pérez M
J Chem Physics (126), 234703-11 (2007)

Differentiation restricted endocitosis of cell penetrating peptides in MDCK cells corresponds with activities of Rho-GTPases
Foerg C, Ziegler U, Fernández-Carneado J, Giralt E and Merkle HP
Pharm Res (24), 628-42 (2007)

The natural product berberine is a human prolyl oligopeptidase inhibitor
Tarrago T, Kichik N, Segu J and Giralt E
ChemMedChem (2), 354-59 (2007)

Evolutionary computation and multimodal search: A good combination to tackle molecular diversity in the field of peptide design
Belda I, Madurga S, Tarrago T, Llora X and Giralt E
Mol Divers (11), 42916 (2007)

Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line
Monge M, Vilaseca M, Soto-Cerrato V, Montaner B, Giralt E and Pérez-Tomás R
Invest New Drugs, 1 (25), 21-29 (2007)

Racemization in suzuki couplings: A quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules
Prieto M, Mayor S, Rodriguez K, Lloyd-Williams P and Giralt E
J Org Chem, 3 (72), 1047-50 (2007)

Microwave-assisted solvent-free regiospecific synthesis of 5-alkylidene and 5-arylidenehydantoins
Lamiri M, Bougrin K, Daou B, Nicolas E, Giralt E and Soufiaoui M
Synth Comm (36), 1575-84 (2006)

Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing
Costa E, Canudas S, Garcia-Bassets I, Pérez S, Fernández I, Giralt E, Azorín F and Espinas ML
Chromosome Res (14), 515-26 (2006)

Efficient preparation of proline N-carboxyanhydride using polymer-supported bases
Gulin OP, Rabanal F, and Giralt E
Org Lett (8), 5385-88 (2006)

Convergent approaches for the synthesis of the antitumoral peptide, Kahalalide F. Study of orthogonal protecting groups
Gracia C, Isidro A, Cruz LJ, Acosta GA, Alvarez M, Cuevas C, Giralt E and Albericio F
J Org Chem (71), 7196-04 (2006)

Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites
Villen J, Rodriguez-Mias R, Nunez J, Giralt E, Sobrino F and Andreu D
Chem Biol, 8 (13), 815-23 (2006)

Antibacterial evaluation of a collection of norfloxacin and ciprofloxacin derivatives against multiresistant bacteria
Vila J, Sanchez-Cespedes J, Sierra JM, Piqueras M, Nicolas E, Freixas J and Giralt E
Int J Antimicrob Ag (28), 19-24 (2006)

Synthetic ligands able to interact with the p53 tetramerization domain. Towards understanding a protein surface recognition event
Martinell M, Salvatella S, Fernández-Carneado J, Gordo S, Feliz M, Menéndez M and Giralt E
ChemBioChem (7), 1105-13 (2006)

A fast and robust 19F-NMR based method for finding new HIV-1 protease inhibitors
Frutos S, Tarragó T and Giralt E
Bioorg Med Chem Lett (16), 2677-81 (2006)

Identification of traditional Chinese medicinal plants with prolyl oligopeptidase inhibitory activity using 19F-NMR
Tarragó T, Frutos S, Rodriguez-Mias R and Giralt E
ChemBioChem (7), 827-33 (2006)

Proteomic analysis of a fraction enriched in cell envelope proteins of Acinetobacter baumannii
Martí S, Sánchez-Cespedes J, Oliveira E, Bellido D, Giralt E and Vila J
Proteomics (6), 82-87 (2006)

Total solid-phase synthesis of the marine cyclodepsipeptide IB-01212
Cruz LJ, Cuevas C, Cañedo L, Giralt E and Albericio F
J Org Chem (71), 3339-44 (2006)

IB-01212, a new cytotoxic cyclodepsipeptide isolated from the marine fungus Clonostachys sp
Cruz LJ, Martinez M, Perez J, Trujillo M, Rodriguez-Mias R, Oliveira E, Giralt E, Albericio F and Canedo LM
J Org Chem (71), 3335-38 (2006)

Mechanistic aspects of CPP-mediated intracellular drug delivery: relevance of CPP self-assembly
Pujals S, Fernández-Carneado J, López C, Kogan M and Giralt E
Biochim Biophys Acta, 3 (1758(3)), 264-79 (2006)

Nanoparticle-mediated local and remote manipulation of protein aggregation
Kogan M, Bastus NG, Amigo R, Grillo D, Araya E, Turiel A, Labarta A, Giralt E and Puntes V
Nano Lett, 1 (6), 110-15 (2006)