Enginyeria metabòlica i teràpia de la diabetis
2008
Hepatic glycogen synthesis in the absence of GK. The case of embryonic liver
Cifuentes D., Martínez-Pons C., García-Rocha M., Galina A., Ribas de Pouplana L. &, Guinovart J.J.
J. Biol. Chem. 29 283, pag. 5642-5649, Vol: 9, Enero (2008)
2007
Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway
Solaz-Fuster M.D., Gimeno-Alcañiz J.V., Ros S., Fernandez-Sanchez M.E., Garcia-Fojeda B., Garcia O.C., Vilchez D., Dominguez J., Garcia-Rocha M., Sanchez-Piris M., Aguado C., Knecht E., Serratosa J., Guinovart J.J., Sanz P. & de Córdoba S.R.
Hum Mol Genet, Vol: (in press) e-pub, Nov (2007)
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Vilchez D., Ros S., Cifuentes D., Pujadas L.l., Vallès J., García-Fojeda B., Criado-García O., Fernández-Sánchez E., Medraño M.I., Domínguez J., García Rocha M., Soriano E., Rodríguez de Córdoba S. & Guinovart J.J.
Nature Neuroscience 10, pag. 1407-1413 (2007)
Tungstate administration improves the sexual and reproductive function in female rats with streptozotocin-induced diabetes
Ballester J., Muñoz M.C., Domínguez J., Palomo M.J., Rivera M., Rigau T., Guinovart J.J. & Rodríguez-Gil J.E.
Hum Reprod, 22, pag. 2128-2135 (2007)
Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells
Piquer S., Barceló-Batllori S., Julià M., Marzo N., Nadal B., Guinovart J.J. & Gomis R.
Biochem Biophys Res Commu 358, pag. 385-391 (2007)
Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism
Fernández-Novell J.M., Rodríguez-Gil J.E., Barberà A., & Guinovart J.J.
Arch Biochem Biophys 457, pag. 29-34 (2007)
2006
Inhibition of GSK3 dependent tau phosphorylation by metals
Gómez-Ramos A., Domínguez J., Zafra D., Corominola H., Gomis R., Guinovart J.J. & Avila J.
Curr Alzheimer Res 3, pag. 123-127 (2006)
Utilisation of citrate and lactate through a lactate dehydrogenase and ATP-regulated pathway in boar spermatozoa
Medrano A., Fernández-Novell J.M., Ramio L., Álvarez J., Goldberg E., Rivera M.M., Guinovart J.J., Rigau T. & Rodríguez-Gil J.E.
Mol Reprod Dev. 73, pag. 369-387 (2006)
Crystal structure of an archaeal glycogen synthase: Insights into oligomerisation and substrate binding of eukaryotic glycogen synthases
Horcajada C., Guinovart J.J., Fita I. & Ferrer J.C.
J. Biol. Chem 281, pag. 2923-2931 (2006)
Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation
Gómez-Ramos A., Domíniguez J.E., Zafra D., Corominola H., Gomis R., Guinovart J.J., & Avila J. J.
Neurosc. Res 83, pag. 264-273 (2006)
2005
Determinant of the nucleocytoplasmic shuttling of muscle glycogen synthase
Cid E., Cifuentes D., Baque S.; Ferrer J.C. & Guinovart J.J.
FEBS J 272, pag. 3197-3213 (2005)
Tungstate treatment improves Leydig cell function in streptozotozin-diabetic rats
Ballester J., Domínguez J., Muñoz M.C., Sensat M., Rigau T., Guinovart J.J. & Rodríguez-Gil J.E.
J Androl 26, pag. 706-715 (2005)
Tungstate decreases weight gain and adiposity of obese rats through increased thermogenesis and lipid oxidation
Claret M., Corominola H., Canals I., Saura J., Barcelo-Batllori S., Guinovart J.J. & Gomis R.
Endocrinology 146, pag. 4362-4369 (2005)
Proteomic identification of the novel anti-obesity agent tungstate targets in adipose tissue from obese rats
Barcelo-Batllori S., Corominola H., Claret M., Canals N., Guinovart J.J. & Gomis R.
Proteomic 5, pag. 4927-4935 (2005)
2004
Regulation of glycogen metabolism in cultured human muscle by the glycogen phosphorylase inhibitor CP-91149
Lerin C., Montelle E., Nolasco T., Garcia-Rocha M., Guinovart J.J. & Gomez-Foix A.M.
Biochem J. 378, pag. 1073-1077 (2004)
Stable and functional regeneration of pancreatic b-cell population by tungstate treatment
Fernandez-Alvarez J., Barbera A., Nadal B., Barcelo S., Piquer S., Claret M., Guinovart J.J. & Gomis R.
Diabetologia 47, pag. 470-477 (2004)
Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2- 13C 2]-glucose
Marin S., Lee W.N., Bassilian S., Lim S., Boros L.G., Centelles J.J., Fernandez-Novell J.M., Guinovart J.J. & Cascante M.
Biochem. J 381, pag. 287-294 (2004)
The presence of a high-Km hexokinase activity in dog, but not in boar, sperm
Fernandez-Novell J.M., Ballester J., Medrano A., Otaegui P.J., Rigau T., Guinovart J.J. & Rodriguez-Gil J.E.
FEBS Letters 570, pag. 211-216 (2004)
Subcellular localization of liver FBPase is modulated by metabolic conditions
Yáñez A. J., García-Rocha M., Bertinat R., Droppelman C., Concha I. I., Guinovart J. J. & Slebe J.C.
FEBS Letters 577, pag. 154-158 (2004)
2003
Modulation of Glucose Transporters in Rat Diaphragm by Sodium Tungstate
Girón D., Caballero J. J., Vargas A. M., Suárez M. D., Guinovart J. J. & Salto R.
FEBS Lett 542, pag. 84-88 (2003)
Control of glycogen deposition
Ferrer J.C., Favre C., Gomis R.R., Fernandez-Novell J.M., Garcia-Rocha M., De La Iglesia N., Cid E. & Guinovart J.J.
FEBS Lett 546, pag. 127-132 (2003)
The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway
Dominguez J.E., Munoz M.C., Zafra D., Sanchez-Perez I., Baque S., Caron M., Mercurio C., Barbera A., Perona R., Gomis R. & Guinovart J.J.
J Biol Chem. 278, pag. 42785-42794 (2003)
Enginyeria metabòlica i teràpia de la diabetis
Joan J. Guinovart
Investigador Principal
Professor (Biochemistry and Molecular Biology Dept. - UB)
Tel Oficina : +34 93 403 71 11
correu-e : joan.guinovart
irbbarcelona.org
Research Associate
Jorge Domínguez
tel +34 93 403 71 63
jorge.dominguezirbbarcelona.org
Mª del Mar Garcia Rocha
tel +34 93 403 71 63
mar.garciairbbarcelona.org
Postdoctoral Fellow
Adelaida Díaz-Vilchis
tel +34 93 403 71 63
adelaida.diazirbbarcelona.org
Delia Zafra
tel +34 93 403 71 63
delia.zafrairbbarcelona.org
Carlos Javier Rodríguez Hernández
tel +34 93 403 71 63
carlos.rodriguezirbbarcelona.org
Jordi Duran
tel. +34 93 403 47 01
jordi.duranirbbarcelona.org
David Vílchez
tel +34 93 403 71 63
david.vilchezirbbarcelona.org
PhD Student
Óscar Blanco Presas
tel +34 93 403 71 63
oscar.blancoirbbarcelona.org
Carles Martínez-Pons
tel +34 93 403 71 63
carles.martinez-ponsirbbarcelona.org
Laura Nocito
tel +34 93 403 71 63
laura.nocitoirbbarcelona.org
Susana Ros
tel +34 93 403 71 63
susana.rosirbbarcelona.org
Jordi Vallès Ortega
tel +34 93 403 71 63
jordi.vallesirbbarcelona.org
Isabel Saez Martínez
tel +34 93 403 71 63
isabel.saezirbbarcelona.org
Research Assistant
Anna Adrover
tel +34 93 403 71 63
anna.adroverirbbarcelona.org
Lab Manager
Carme Carrión i Rivas
tel +34 93 403 71 61
carme.carrionirbbarcelona.org
Lab Technician
Mª Carmen Romero
tel +34 93 403 71 63
maria.romeroirbbarcelona.org
Emma Veza
tel +34 93 403 71 63
emma.vezairbbarcelona.org
