24 July 2014
Researchers identify a key molecule in flies that adjusts energy use under starvation conditions
Scientists at IRB Barcelona have observed that, when deprived of food, flies that do not express p53 show poor management of energy store.
The study, published today in Cell Reports, further supports the involvement of this molecule—traditionally associated with tumour suppression—in metabolism.
The researchers provide new insights to study p53 function in metabolic diseases such as diabetes and obesity.
9 July 2014
The scientific community does not give up its fight against Alzheimerís disease
Around 160 scientists, brought together by IRB Barcelona and the BBVA Foundation in a Barcelona Biomed Conference, are discussing the latest research into one of the hallmarks of Alzheimer’s disease, the amyloid-beta protein that is the major component of the plaques that are characteristic of this debilitating disorder.
According to data from Alzheimer's Disease International in 2013, an estimated 135 million people worldwide will be suffering from dementia in 2050, Alzheimer’s disease being the most prevalent. This condition currently affects over 40 million people but is very strongly age-related, giving rise to the prospect of a ‘21st century plague’ affecting the aging populations across the globe.
A recent report from the Cleveland Clinic published in July 3, indicates that 99.6% of the clinical trials for Alzheimer´s disease have failed, with the result that much of the pharmaceutical industry is discouraged and uncertain as to how to proceed. The scientific community, however, is making substantial progress in understand the underlying causes of the disease, an essential factor in the rational design of innovative therapeutic strategies.
30 June 2014
A key component of cell division comes to light
A breakthrough at IRB Barcelona fills a knowledge gap in understanding how the cell division apparatus, the mitotic spindle, is formed.
The in vivo visualization and monitoring of the starting points of microtubules — filaments responsible for organising the mitotic spindle — provides novel insight into the dynamic architecture of this structure.
The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and that are used in chemotherapy.
23 June 2014
The colon has a safety mechanism that restricts tumour formation
When adenomas appear in the colon, the same cells of the tissue produce a molecule that neutralizes its progression.
Adenomas, which are highly prevalent in the population, provide the substrate on which carcinomas develop.
20 June 2014
IRB to participate in the international biotech fair par excellence
Twenty-two companies and four institutes form the Catalan delegation organised by Biocat for the San Diego gathering.
12 June 2014
The transmission of information via proteins could revolutionize drug discovery
A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.
3 June 2014
ICREA Academia Award for Antonio Zorzano
IRB hosts 13 researchers who have received the ICREA seal of recognition
2 June 2014
Discovery of why colon cancer metastasis always follows the same invasive pattern
Roger Gomis’ team, in collaboration with another two groups in IRB Barcelona’s Oncology Programme, reveal in Nature Cell Biology the genes and mechanisms that allow liver metastasis to colonize the lung.
The breakthrough introduces a new concept of metastasis from metastasis, which may require a distinct clinical treatment to metastases generated from the primary tumour.
The study has been partially supported by the BBVA Foundation, which provides two IRB groups signing this article with structural funds.
2 June 2014
Joan Massaguť. 2014 National Culture Award
Today the cofounder and current president of the International Scientific Board of IRB receives the highest recognition in the field of culture in Catalonia
31 May 2014
More than 300 people participate in the charity wine-tasting ĎVi per Vidaí to raise funds for research into metastasis