IRB Barcelona News - Scientific
24 July 2014
Researchers identify a key molecule in flies that adjusts energy use under starvation conditions
Scientists at IRB Barcelona have observed that, when deprived of food, flies that do not express p53 show poor management of energy store.
The study, published today in Cell Reports, further supports the involvement of this molecule—traditionally associated with tumour suppression—in metabolism.
The researchers provide new insights to study p53 function in metabolic diseases such as diabetes and obesity.
30 June 2014
A key component of cell division comes to light
A breakthrough at IRB Barcelona fills a knowledge gap in understanding how the cell division apparatus, the mitotic spindle, is formed.
The in vivo visualization and monitoring of the starting points of microtubules — filaments responsible for organising the mitotic spindle — provides novel insight into the dynamic architecture of this structure.
The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and that are used in chemotherapy.
23 June 2014
The colon has a safety mechanism that restricts tumour formation
When adenomas appear in the colon, the same cells of the tissue produce a molecule that neutralizes its progression.
Adenomas, which are highly prevalent in the population, provide the substrate on which carcinomas develop.
12 June 2014
The transmission of information via proteins could revolutionize drug discovery
A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.
2 June 2014
Discovery of why colon cancer metastasis always follows the same invasive pattern
Roger Gomis’ team, in collaboration with another two groups in IRB Barcelona’s Oncology Programme, reveal in Nature Cell Biology the genes and mechanisms that allow liver metastasis to colonize the lung.
The breakthrough introduces a new concept of metastasis from metastasis, which may require a distinct clinical treatment to metastases generated from the primary tumour.
The study has been partially supported by the BBVA Foundation, which provides two IRB groups signing this article with structural funds.
27 May 2014
Researchers identify a new suppressor of breast metastasis to the lung
The research headed by Roger Gomis at IRB Barcelona, with the collaboration of Joan Massagué, describes that the loss of the suppressor RARRES3 promotes the colonization of breast cancer cells in the lung.
RARRES3 could prove to be a useful marker to identify patients with a greater risk of metastasis, as well as providing a target for the development of a specific treatment for preventive strategies after removal of the primary tumour.
The study has received, among others, funding from the BBVA Foundation, which provides structural funds for the development of research addressing metastasis at IRB Barcelona.
9 April 2014
Identified a new possible target to combat muscle wasting
Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice.
The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia.
27 March 2014
Researchers at IRB discover a key regulator of colon cancer
The team headed by Angel Rodríguez Nebreda, ICREA researcher at IRB, identifies for the first time in mice that the p38 MAPK protein is required for the survival and proliferation of colon cancer cells.
In the same study the scientists demonstrate that a p38 inhibitor that has been used in clinical trials for inflammatory diseases shrinks the tumours in mice.
The study, published today in Cancer Cell, has received funding from the BBVA Foundation, the European project InflaCare, the Spanish Government, and the European Research Council (ERC).
21 March 2014
A study using Drosophila flies reveals new regulatory mechanisms of cell migration
The study by Sofia J. Araújo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial.
6 March 2014
Protein reelin rescues cognitive impairment in animal models of Alzheimerís disease
The study describes the neuroprotective effect of reelin in neurodegenerative diseases.
Co-directed by Eduardo Soriano and Lluís Pujadas, from the University of Barcelona, and the CIBERNED network, the study has involved Bernat Serra-Vidal, Ernest Giralt and Natàlia Carulla, all three scientists at IRB.