IRB Barcelona News - Scientific
20 November 2013
A study on cell migration provides insights into the movement of cancer cells
Using Drosophila melanogaster, researchers at IRB Barcelona discover that during multiple cell migrations a single cell can act as leader, dragging the others with it.
10 October 2013
Scientists disclose minute-by-minute details of the biological clock of skin stem cells
Researchers lead by Salvador Aznar Benitah describe in detail the cyclic activity of the genes in skin stem cells during the course of a day.
The correct balance of the biological clock of stem cells affects their function, and its disruption causes aging and can lead to predisposition to skin cancer.
30 September 2013
And in the beginning was histone 1
A team at IRB Barcelona identifies an essential protein for embryonic viability during the first cell divisions in the fly Drosophila.
This protein, called dBigH1, which is a variant of histone 1, could also be associated with fertility issues.
27 September 2013
Alterations in the interactions between organelles within neurons cause obesity
Researchers at IRB Barcelona participate in a study headed by IDIBAPS that sheds light on the molecular causes of obesity.
The control of hunger and body weight is governed by the central nervous system, and the region called the hypothalamus plays a crucial role. In normal conditions, the hormone leptin suppresses appetite and reduces body weight by activating the POMC neurons of the hypothalamus.
In obesity there is leptin resistance and this hormone loses its capacity to exert its effects on appetite and weight. The neurobiological causes of this alteration are among the main enigmas in the field of obesity research.
This study describes a molecular mechanism in POMC neurons that explains how leptin resistance comes about and how appetite control becomes disrupted.
17 September 2013
A protein that can mean life or death for cells
A research team at IRB discovers that Mitofusin 2 confers the cell with the sensitivity to understand its state of health, and determine whether it should be repaired or undergo apoptosis
With this new function, Mitofusin 2 becomes a viable target to intervene in diseases such as neurodegeneration and cancer
4 September 2013
IRB and PharmaMar invent a method to reproduce marine substances of pharmacological interest
Chemists from the Institute of Research in Biomedicine (IRB) and from the R+D department of PharmaMar have devised a new synthesis method with pipecolidepsin A, a compound that is active against eleven types of cancers and property of PharmaMar.
This advance opens the door to copying and improving 38 natural molecules derived from marine sponges that are very promising for the treatment of various diseases.
18 July 2013
A nanosensor made of DNA segments
20 June 2013
Lab reproduction of a marine compound with antibiotic properties
Chemists at IRB Barcelona synthesize baringolin, a substance isolated from the depths of the sea by the pharmaceutical company BioMar S.A. At very small doses this compound inhibits the growth of antibiotic-resistant bacteria.
18 June 2013
Pioneering breakthrough of chemical nanoengineering to design drugs controlled by light
Researchers at IRB Barcelona and IBEC achieve photo-switchable molecules to control protein-protein interactions in a remote and non-invasive manner.
These tools will serve as a prototype to develop photo-switchable drugs, whose effects would be limited to a given region and time, thus reducing the side effects on other regions.
The article, cover and “Very Important Paper” of Angewandte Chemie, is a highlighted result of the European project “OpticalBullet”, funded by the European Research Council (ERC) and in which the two institutes participate.
13 June 2013
Discovered a hidden physical code that modulates genome expression