IRB Barcelona News - Scientific
6 March 2014
Protein reelin rescues cognitive impairment in animal models of Alzheimerís disease
The study describes the neuroprotective effect of reelin in neurodegenerative diseases.
Co-directed by Eduardo Soriano and Lluís Pujadas, from the University of Barcelona, and the CIBERNED network, the study has involved Bernat Serra-Vidal, Ernest Giralt and Natàlia Carulla, all three scientists at IRB.
27 February 2014
Researchers reveal the dual role of brain glycogen
Two articles produced by Joan Guinovart’s lab answer key questions regarding the activity of glycogen in neurons.
An excess of glycogen causes neuronal death while a lack of this polysaccharide endangers these cells under oxygen shortage to the brain.
24 February 2014
A step closer to putting together the vital puzzle of the bacteria Escherichia coli
E. coli is the best known model organism at the molecular level. It is used extensively for biotechnology production, and its infectious strains are of biomedical interest.
The article in Nature Biotecnology is a collaborative effort between biologists, biochemists and bioinformaticians at the Craig Venter Institute, the University of Virginia, and the Institute for Research in Biomedicine (IRB).
The team of 18 researchers presents the first map of key interactions between the molecular components of the bacteria, and allow us to understand how its most intimate machinery works.
19 February 2014
Scientists discover a new kind of DNA intercalator
DNA intercalators developed for use in chemotherapy interfere with the DNA of cancer cells, thus eliminating them.
Researchers at IRB, in collaboration with a team in Sweden, publish the study in Angewandte Chemie.
11 February 2014
First observation of a human HAT, key proteins in numerous pathologies
Researchers at IRB Barcelona, BSC, and the University of Bern observe the first structure of a human HAT at low resolution.
HAT amino acid transporters are involved in pathologies such as aminoacidurias, cancer, viral infections and cocaine addiction.
The breakthrough published in the Proceedings of the National Academy of Science USA allows researchers to delve into the functions of HATs and to address the rational drug design of inhibitors.
The study has been partially funded by the European project EDICT (European Drug Initiative on Channels and Transporters), devoted to increasing the number of membrane protein structures available.
30 January 2014
Scientists unveil a molecular mechanism that controls plant growth and development
Researchers at IRB and IBMB-CSIC, in Barcelona, and at the University of Wageningen, in the Netherlands, reveal how auxin hormone-regulated proteins activate developmental genes in plants.
Auxins are key components of plant growth and have many applications in agriculture. The biomedical application of these hormones are also being addressed.
The study is published today in the scientific journal Cell.
19 December 2013
ChroGPS, a new generation visual browser of the epigenome
This is a software application that provides easily interpretable maps from which to analyse and understand the immense volume of epigenetic and genetic data available.
The work is the fruit of collaboration between biostatisticians, biocomputational researchers and molecular biologist at IRB Barcelona. The capacity of ChroGPS is described in an article in Nucleic Acids Research.
20 November 2013
A study on cell migration provides insights into the movement of cancer cells
Using Drosophila melanogaster, researchers at IRB Barcelona discover that during multiple cell migrations a single cell can act as leader, dragging the others with it.
10 October 2013
Scientists disclose minute-by-minute details of the biological clock of skin stem cells
Researchers lead by Salvador Aznar Benitah describe in detail the cyclic activity of the genes in skin stem cells during the course of a day.
The correct balance of the biological clock of stem cells affects their function, and its disruption causes aging and can lead to predisposition to skin cancer.
30 September 2013
And in the beginning was histone 1
A team at IRB Barcelona identifies an essential protein for embryonic viability during the first cell divisions in the fly Drosophila.
This protein, called dBigH1, which is a variant of histone 1, could also be associated with fertility issues.