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Research Programmes

Cell & Developmental Biology

Cell division laboratory

Cayetano González

Cayetano González

Group Leader
ICREA Research Professor

Office Tel : +34 93 403 71 91
Lab Tel : +34 93 403 70 18
e-mail : gonzalezirbbarcelona.org

Research Interests

We study the mechanisms of cell division through a multidisciplinary approach that combines genetics, and molecular biology and advanced microscopy. As model systems, we use Drosophila and also cultured cells derived from vertebrates.

Research Lines

Protein Traps: Subcellular localisation is a key aspect of protein function.
We have now automated a protein trap protocol (Reviewed in Gonzalez and Bejarano, 2000) which is being applied in several high-content screens.

Spindle assembly in vivo: Direct visualisation is now mandatory to unravel the complex processes that occur within the living cell. Using protocols developed in our laboratory,  we are obtaining new data on the behaviour of specific proteins labelled with florescent tags (Rebollo and Gonzalez , 2000; Lange et al., 2002; Sampaio et al., 2001; Rebollo et al., 2004).

Molecular analysis of centrosomes. (Lange et al., 2002; Tavosanis and Gonzalez, 2003). We have recently cloned the gene that encodes a centriolar protein. Our laboratory has access to mutant alleles, functional GFP fusions and antibodies, that will be all instrumental tools in the molecular dissection of this organelle.

Modelling cancer in Drosophila: We are starting to use Drosophila to study some basic principles regarding cell proliferation and malignant growth (Caussinus and González, 2005; Wodarz & Gonzalez, 2006. Previews, Cell).

Funding

This group is financially supported by the following:

  • VI Framework Programme Grants, EU
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (Government of Catalonia)
More info

Scientific publications search

Scientific publications search


Research Directory

Core facilities and Services Directory

  • Generalitat de catalunya
  • Generalitat de catalunya. Salut
  • Universidad de Barcelona
  • Parc cientific

Institute for Research in Biomedicine (IRB Barcelona)
Parc Científic de Barcelona
C/ Baldiri Reixac 10
08028 Barcelona - Spain
Tel: +34 93 402 02 50 | Fax: +34 93 403 71 14
infoarrobairbbarcelona.org