Cell division laboratory / Cayetano Gonzalez: Cell Division Laboratory / Cell & Developmental Biology / IRB Barcelona

Cell division laboratory

Cayetano González

Group Leader
ICREA Research Professor
Office Tel : +34 93 40 37191
Lab Tel : +34 93 403 70 18
e-mail : gonzalezirbbarcelona.org

Research Interests

We study the mechanisms of cell division through a multidisciplinary approach that combines genetics, and molecular biology and advanced microscopy. As model systems, we use Drosophila and also cultured cells derived from vertebrates.

Research Lines

Protein Traps: Subcellular localisation is a key aspect of protein function.
We have now automated a protein trap protocol (Reviewed in Gonzalez and Bejarano, 2000) which is being applied in several high-content screens.

Spindle assembly in vivo: Direct visualisation is now mandatory to unravel the complex processes that occur within the living cell. Using protocols developed in our laboratory, we are obtaining new data on the behaviour of specific proteins labelled with florescent tags (Rebollo and Gonzalez , 2000; Lange et al., 2002; Sampaio et al., 2001; Rebollo et al., 2004).

Molecular analysis of centrosomes. (Lange et al., 2002; Tavosanis and Gonzalez, 2003). We have recently cloned the gene that encodes a centriolar protein. Our laboratory has access to mutant alleles, functional GFP fusions and antibodies, that will be all instrumental tools in the molecular dissection of this organelle.

Modelling cancer in Drosophila: We are starting to use Drosophila to study some basic principles regarding cell proliferation and malignant growth (Caussinus and González, 2005; Wodarz & Gonzalez, 2006. Previews, Cell).

Funding

This group is financially supported by the following:

VI Framework Programme Grants, EU
Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
Generalitat de Catalunya (Government of Catalonia)

More info

Cell division laboratory

Selected publications

Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth
Rossi F, Gonzalez C.
Embo Rep, 2 (13), 1-162 (2012)

Drosophila neuroblasts retain the daughter centrosome
Januschke J, Llamazares S, Reina J and Gonzalez C.
Nat Commun (2), 243 (2011)

Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 6012 (330), 1824-7 (2010)

Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts
Rebollo E, Roldán M and Gonzalez C.
Development, 20 (13), 3393-7 (2009)

Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability
Castellanos E, Dominguez P and Gonzalez C.
Curr Biol, 16 (18), 1209-14 (2008)

All publications list

Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability
Delgehyr N, Wieland U, Rangone H, Pinson X, Mao G, Dzhindzhev NS, McLean D, Riparbelli MG, Llamazares S, Callaini G, Gonzalez C and Glover DM.
Proc Natl Acad Sci U S A (2012)

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics
Haupt A, Joberty G, Bantscheff M, Frohlich H, Stehr H, Schweiger MR, Fischer A, Kerick M, Boerno ST, Dahl A, Lappe M, Lehrach H, Gonzalez C, Drewes G and Lange BM.
Bmc Cancer, 1 (12), 38 (2012)

An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts
Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SS, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, Wang H.
Dev Cell, 3 (21), 520 (2011)

Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal
Chang KC, Garcia-Alvarez G, Somers G, Sousa-Nunes R, Rossi F, Lee YY, Soon SB, Gonzalez C, Chia W and Wang H.
Dev Cell, 5 (19), 778-85 (2010)

Neural stem cells: the need for a proper orientation
Lesage B, Gutierrez I, Martí E and Gonzalez C.
Curr Opin Genet Dev, 4 (20), 438-42 (2010)

Time-lapse imaging of embryonic neural stem cell division in Drosophila by two-photon microscopy
Rebollo E and Gonzalez C.
Curr Protoc Stem Cell Biol (Chapter 1), Unit1H.2 (2010)

The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
Januschke J and Gonzalez C.
J Cell Biol, 5 (188), 693-706 (2010)

Biased segregation of DNA and centrosomes: moving together or drifting apart?
Tajbakhsh S and Gonzalez C.
Nat Rev Mol Cell Bio, 11 (10), 804-10 (2009)

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
Martinez AM, Schuettengruber B, Sakr S, Janic A, Gonzalez C and Cavalli G.
Nat Genet, 10 (41), 1076-82 (2009)

Below the convergence
Gonzalez C.
Curr Biol, 8 (19), R313-4 (2009)

Centrosome function during stem cell division: the devil is in the details
Gonzalez C.
Curr Opin Cell Biol, 6 (20), 694-8 (2008)

Drosophila asymmetric division, polarity and cancer
Januschke J and Gonzalez C.
Oncogene, 55 (27), 6994-7002 (2008)

Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes
Dyer N, Rebollo E, Dominguez P, Elkhatib N, Chavrier P, Daviet L, Gonzalez C and Gonzalez M
Development, 24 (134), 4437-47 (2007)

Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila
Varmark H, Llamazares S, Rebollo E, Lange B, Reina J, Schwarz H and Gonzalez C
Curr Biol, 20 (17), 1735-45 (2007)

Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
Gonzalez C.
Nat Rev Genet, 6 (8), 462-72 (2007)

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells
Rebollo E, Sampaio P, Januschke J, Llamazares S, Varmark H and González C.
Dev Cell, 3 (12), 467-74 (2007)

Localized transfection with magnetic beads coated with PCR products and other nucleic acids
Santori MI, González C, Serrano L and Isalan M
Nat Protoc, 2 (1), 526-31 (2006)

Connecting cancer to the asymmetric division of stem cells
Wodarz A and González C
Cell (124), 1121-23 (2006)

Localized transfection on arrays of magnetic beads coated with PCR products
Isalan M, Santori MI, Gonzalez C and Serrano L
Nat Methods, 2 (2), 113-118 (2005)

Structure and microtubule-nucleation activity of isolated Drosophila embryo centrosomes characterized by whole mount scanning and transmission electron microscopy
Lange BM, Kirfel G, Gestmann I, Herzog V and González C
Histochem Cell Biol, 124 (3-4), 325-334 (2005)

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Caussinus E and Gonzalez C
Nat Genet, 37 (10), 1125-1129 (2005)

Time-lapse imaging of male meiosis by phase-contrast and fluorescence microscopy
Rebollo E and González C
In “Drosophila Cytogenetics Protocols”, Methods Mol Biol, 247, 77-87 (2004)

Contribution of noncentrosomal microtubules to spindle assembly in Drosophila spermatocytes
Rebollo E, Llamazares S, Reina J and Gonzalez C
PLoS Biol, 2 (1), 54-64 (2004)

Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes
Barbosa V, Gatt M, Rebollo E, Gonzalez C and Glover DM
J Cell Sci, 116 (Pt 5), 929-941 (2003)

Cell division: the place and time of cytokinesis
Gonzalez C
Curr Biol, 13 (9), 363-365 (2003)

gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila
Tavosanis G and Gonzalez C
Proc Natl Acad Sci U SA, 100 (18), 10263-10268 (2003)

Cell division laboratory

Cayetano González
Group Leader
ICREA Research Professor

Office Tel : +34 93 40 37191
Lab Tel : +34 93 403 70 18
e-mail : gonzalezirbbarcelona.org

Postdoctoral Fellows
Fabrizio Rossi
tel +34 93 40 37018
e-mail: fabrizio.rossiirbbarcelona.org

Giulia Pollarolo
e-mail: giulia.pollaroloirbbarcelona.org

Jens Januschke
tel +34 93 40 37018
e-mail: januschkeirbbarcelona.org

José Reina
tel +34 93 40 37018
e-mail: reinairbbarcelona.org

Judit Pampalona
tel +34 93 40 37018
e-mail: judit.pampalonairbbarcelona.org

Kazuya Hashiyama
tel +34 93 40 37018
e-mail: kazuya.hashiyamairbbarcelona.org

Zhanna Shcheprova
tel +34 93 40 37018
e-mail: zhanna.shcheprovairbbarcelona.org

PhD Students
Eulàlia Scheenaard
tel +34 93 40 37018
e-mail: eulalia.scheenaardirbbarcelona.org

Research Assistants
Jan Peter Heinen
tel +34 93 40 37018
e-mail: peter.heinenirbbarcelona.org

Salud Llamazares
tel +34 93 40 37018
e-mail: llamazaresirbbarcelona.org

Lab Technicians
Andrea Durán
tel +34 93 40 37018
e-mail: andrea.duranirbbarcelona.org

Administrative Assistant
Sandra Ricol
tel +34 93 40 39982
e-mail: sandra.ricolirbbarcelona.org

Cell division laboratory

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28 January 2012
El Periódico de Catalunya
Science’s “Jackpot”
25 January 2012
El Periódico de Catalunya
Europe awards scientists working in Catalonia with seven elite grants
24 January 2012
ABC
IRB holds 20% of the EU grants awarded to Spain
25 January 2012
La Vanguardia
Europe recognizes Catalonia as the motor of the scientific excellence in Spain
24 January 2012
Institute News
IRB Barcelona receives 20% of the ERC Advanced Grants awarded in Spain
Professors Cayetano González, Angel R. Nebreda and Modesto Orozco have each been awarded an ERC Advanced Grant, the first two in the category of Life Sciences and the last one in Physical Sciences and Engineering.

Only 13% of European researchers who have presented a project in the 2011 call passed the screening process.

Each project will receive funding of approx. 2.5 million euros over five years.
30 March 2011
Science News
Biased segregation of centrosomes in stem cells
9 March 2011
Química e Industria
The silencing of some specific germline genes could reduce brain tumours
25 January 2011
La Vanguardia
Gold Science
28 December 2010
Ciencias Medicas News
Investigadores españoles identifican en la mosca del vinagre genes que inhiben el crecimiento tumoral
28 December 2010
Jano.es
Investigadores españoles identifican en la mosca del vinagre genes que inhiben el crecimiento tumoral

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Cell division laboratory

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