IRB Barcelona - Chemistry & Molecular Pharmacology - Xavier Salvatella: Laboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

Xavier Salvatella

Principal Investigator

Office Tel : +34 93 402 04 59
Lab Tel : +34 93 402 04 61
e-mail : xavier.salvatellairbbarcelona.org

Background

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Laboratory of Molecular Biophysics

2008

Influence of the fluctuations of the alignment tensor on the analysis of the structure and dynamics of proteins using residual dipolar couplings
Salvatella X, Richter B and Vendruscolo M
J Biomol NMR 40, pag. 71-81 (2008)

2007

Protein structure determination using NMR chemical shifts
A. Cavalli, X. Salvatella, C. M. Dobson and M. Vendruscolo
Proc. Natl. Acad. Sci. USA 104, pag. 9615-9620 (2007)

2006

The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native state ensembles of proteins
B. Richter, J. Gsponer, P. Varnai, X. Salvatella and M. Vendruscolo
J. Biomol. NMR 37, pag. 117-135 (2006)

2005

Determination of the folding transition states of barnase by using F_I -value-restrained simulations validated by double mutant F_IJ -values
X. Salvatella, C. M. Dobson, A. R. Fersht, M. Vendruscolo
Proc. Natl. Acad. Sci. USA 102, pag. 12389-12394 (2005)

2004

Characterizing low populated folding intermediates of an SH3 domain by NMR spectroscopy
D. M. Korzhnev, X. Salvatella, M. Vendruscolo , A. A. Di Nardo, A. R. Davidson, C. M. Dobson and L. E. Kay
Nature 430, pag. 586-590 (2004)