Signalling and Cell Cycle Laboratory

Angel R. Nebreda

Group Leader
ICREA Research Professor
Office Tel : +34 93 40 31379

e-mail : angel.nebredairbbarcelona.org

Background

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

1. Mechanisms of signal integration by p38 MAP kinases and their role in cancer
2. Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.

Signalling and Cell Cycle Laboratory

Genetic analysis of specific and redundant roles for p38{alpha} and p38{beta} MAPKs during mouse development.
Del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR.
Proc Natl Acad Sci U S A, 108 (31), 12764-9 (2011)

Whole genome analysis of p38 SAPK-mediated gene expression upon stress
Ferreiro F, Joaquin M, Islam K, Gomez G, Barragan M, Lombardía L, Domínguez O, Pisano DG, Lopez-Bigas N, Nebreda AR and Posas F
BMC Genomics, 11, 144 (2010)

Deconstructing ERK signaling in tumorigenesis
Santamaria PG and Nebreda AR
Mol. Cell., 38, 3-5 (2010)

A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry
Ruiz EJ, Vilar, M and Nebreda AR
Curr. Biol. (in press) (2010)

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in skeletal muscle differentiation
Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Muñoz-Canoves P and Nebreda AR
EMBO J. (in press) (2010)

p38delta and PDK1: kinase switches for insulin secretion
Cuenda A and Nebreda AR
Cell, 136, 209-210 (2009)

Cell density-dependent inhibition of EGFR signaling by p38α MAP kinase via Sprouty2 downregulation
Swat A, Dolado I, Rojas JM and Nebreda AR
Mol. Cell. Biol., 29, 3332-3343 (2009)

Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes
Git A, Allison R, Perdiguero E, Nebreda AR, Houliston E, Standart N
RNA, 15, 1121-1133 (2009)

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez-Capetillo O and Nebreda AR
Mol. Cell. Biol., 29, 4341-4351 (2009)

Signal integration by JNK and p38 MAPK pathways in cancer development
Wagner EF and Nebreda AR
Nat. Rev. Cancer, 9, 537-549 (2009)

Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A
Dinarina A, Santamaría PG and Nebreda AR
FEBS Lett., 583, 2772-2778 (2009)

p27kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage
Cuadrado M, Gutierrez-Martinez P, Aneta S, Nebreda AR and Fernandez-Capetillo O
Cancer Res., 69, 8726-8732 (2009)

UV-induced downregulation of the CDC25B protein in human cells
Lemaire M, Ducommun B and Nebreda AR
FEBS Lett., 584, 1199-1204 (2009)

Regulation of tumorigenesis by p38alpha MAP kinase
Dolado I and Nebreda AR
Topics Current Gen, 20, 99-128 (2008)

Negative regulation of cell cycle progression by RINGO/Speedy E.
Dinarina A, Ruiz EJ, O´Loghlen A, Mouron S, Perez L and Nebreda AR
Biochem. J., 410, 535-542 (2008)

A role for p38alpha mitogen-activated protein kinase in embryonic cardiac differentiation
Hernández-Torres F, Martínez-Fernández S, Zuluaga S, Nebreda AR, Porras A, Aránega AE, Navarro F
FEBS Lett., 582, 1025-1031 (2008)

The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner
Jagemann LR, Pérez-Rivas LG, Ruiz EJ, Ranea JA, Sánchez-Jiménez F, Nebreda AR, Alba E. and Lozano J.
J. Biol. Chem., 283, 17450-17462 (2008)

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure
Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR and Pasparakis M
EMBO Rep., 9, 1048-1054 (2008)

Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO but not CDK/cyclin via site-specific phosphorylation
Ruiz EJ, Hunt T and Nebreda AR
Mol. Cell., 32, 210-220 (2008)

AKT and oxidative stress team up to kill cancer cells
Dolado I and Nebreda AR
Cancer Cell, 14, 427-429 (2008)

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1
Zuluaga S, Alvarez-Barrientos A, Gutiérrez-Uzquiza A, Benito M, Nebreda AR and Porras A
Cell Signal., 19, 62-74 (2007)

p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis
Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A and Nebreda AR
Cancer Cell, 11, 191-205 (2007)

A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis
Cuadrado A, Lafarga V, Cheung P, Dolado I, Llanos S, Cohen P and Nebreda AR
EMBO J., 26, 2115-2126 (2007)

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M and Nebreda AR
Nature Genet., 39, 750-758 (2007)

The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes
Meissner JD, Chang KC, Kubis HP, Nebreda AR, Gros G and Scheibe RJ
J. Biol. Chem., 282, 7265-7275 (2007)

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum
Zuluaga S, Gutiérrez-Uzquiza A, Bragado P, Álvarez-Barrientos A, Benito M, Nebreda AR and Porras A.
FEBS Lett., 581, 3819-3825 (2007)

A combination of neutral loss and targeted product ion scanning with two enzymatic digestions facilitates the comprehensive mapping of phosphorylation sites
Casado-Vela J, Ruiz E J, Nebreda A R and Casal JI
Proteomics, 7, 2522-2529 (2007)

p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents
Lafarga V, Cuadrado A and Nebreda AR.
Cell Cycle, 6 (2319), 2322 (2007)

New insights into RSK activation and hematopoietic cancer
Cuadrado A and Nebreda AR
Cancer Cell 12, 187-189. (2007)., 12, 187-189 (2007)

Regulation of skeletal muscle gene expression by p38 MAP kinases
Lluís F, Perdiguero E, Nebreda AR and Muñoz-Cánoves P
Trends Cell Biol, 16, 36-44 (2006)

Proteomic analysis of p38alpha mitogen-activated protein kinase-regulated changes in membrane fractions of RAS-transformed fibroblasts
Alfonso P, Dolado I, Swat A, Núñez A, Cuadrado A, Nebreda AR and Casal JI
Proteomics, 6, 262-271 (2006)

TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes
Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R and Nebreda AR
Biochem. J., 396, 163-172 (2006)

CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, Arthur JSC, Tessier-Lavigne M, Gaestel M., Cuenda A and Cohen P.
Cell. Signal., 18, 1897-1905 (2006)

CDK activation by non-cyclin proteins
Nebreda AR
Curr. Opin. Cell Biol., 18, 192-198 (2006)

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses
Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, Davis RJ and Platanias LC
Cancer Res., 66, 6763-6771 (2006)

Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation
Gutierrez GJ, Vögtlin A, Castro A, Ferby I, Salvagiotto G, Ronai Z, Lorca T and Nebreda AR.
Nature Cell Biol., 8, 1084-1094 (2006)

Protein kinases and phosphatases as therapeutic targets in cancer
Ventura JJ and Nebreda AR
Clin. Transl. Oncol., 8, 153-160 (2006)

CDC25B phosphorylation by p38 and MK-2
Lemaire M, Froment C, Boutros R, Mondesert O, Nebreda AR, Monsarrat B and Ducommun B
Cell Cycle, 5, 1649-1653 (2006)

Characterization of a novel family of cyclin-dependent kinase activators
Dinarina A, Perez LH, Davila A, Schwab M, Hunt T and Nebreda AR
Biochem J., 386, 349-355 (2005)

Mitochondrial reactive oxygen species activation of p38 MAPK is required for hypoxia signaling
Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ and Chandel NS
Mol. Cell. Biol., 25, 4853-4862 (2005)

p38alpha MAPK is required for contact inhibition
Faust D, Dolado I, Cuadrado A, Oesch F, Weiss C, Nebreda AR and Dietrich C
Oncogene, 24, 7941-7945 (2005)

Phosphorylation of EEA1 by p38MAP kinase regulates mu opioid receptor endocytosis
Macé G, Miaczynska M, Zerial M and Nebreda AR
EMBO J. 24, 24, 3235-3246 (2005)

NOGO-B is a new physiological substrate for MAPKAP-K2
Rousseau R, Peggie M, Campbell DG, Nebreda AR and Cohen P
Biochem. J., 391, 433-440 (2005)

Signalling and Cell Cycle Laboratory

Angel R. Nebreda
Group Leader
ICREA Research Professor

Office Tel : +34 93 40 31379

e-mail : angel.nebredairbbarcelona.org

Research Associates
Ana Igea
tel +34 93 40 20596
e-mail: ana.igeairbbarcelona.org

Ivan Del Barco
tel +34 93 40 20596
e-mail: ivan.delbarcoirbbarcelona.org

Postdoctoral Fellows
Elisa Isabel Rivas
tel +34 93 40 20596
e-mail: elisa.rivasirbbarcelona.org

Irene Amata
tel +34 93 40 20596
e-mail: irene.amatairbbarcelona.org

Juan Manuel Murillo
tel +34 93 40 20596
e-mail: juanmanuel.murilloirbbarcelona.org

Sandra Colié
tel +34 93 40 20597
e-mail: sandra.colieirbbarcelona.org

Sebastian Martin Real
tel +34 93 40 20597
e-mail: sebastian.realirbbarcelona.org

PhD Students
Begoña Cánovas
tel +34 93 40 20596
e-mail: begona.canovasirbbarcelona.org

Carmen Lorena Pereira
tel +34 93 40 20596
e-mail: lorena.pereirairbbarcelona.org

Jalaj Gupta
tel +34 93 40 20596
e-mail: jalaj.guptairbbarcelona.org

Jessica Vitos
tel +34 93 40 20596
e-mail: jessica.vitosirbbarcelona.org

Natalia Trempolec
tel +34 93 40 20596
e-mail: natalia.trempolecirbbarcelona.org

Research Assistants
Antonio Núñez
tel +34 93 40 20596
e-mail: antonio.nunezirbbarcelona.org

Lorena Ramírez
tel +34 93 40 20597
e-mail: lorena.ramirezirbbarcelona.org

Lab Technicians
Elisabet Llonch
tel +34 93 40 20596
e-mail: elisabet.llonchirbbarcelona.org

Signalling and Cell Cycle Laboratory

• 28 January 2012
  El Periódico de Catalunya
  Science’s “Jackpot”
  
• 25 January 2012
  El Periódico de Catalunya
  Europe awards scientists working in Catalonia with seven elite grants
  
• 24 January 2012
  ABC
  IRB holds 20% of the EU grants awarded to Spain
  
• 25 January 2012
  La Vanguardia
  Europe recognizes Catalonia as the motor of the scientific excellence in Spain
  
• 24 January 2012
  Institute News
  IRB Barcelona receives 20% of the ERC Advanced Grants awarded in Spain
  

  Professors Cayetano González, Angel R. Nebreda and Modesto Orozco have each been awarded an ERC Advanced Grant, the first two in the category of Life Sciences and the last one in Physical Sciences and Engineering.

  Only 13% of European researchers who have presented a project in the 2011 call passed the screening process.

  Each project will receive funding of approx. 2.5 million euros over five years.

• 20 July 2010
  Europa Press
  El IRB Barcelona ficha a Ángel Nebreda del CNIO para ampliar el programa de cáncer
  
• 20 July 2010
  EcoDiario
  El IRB Barcelona ficha a Ángel Nebreda del CNIO para ampliar el programa de cáncer
  
• 20 July 2010
  ABC
  El IRB ficha a Ángel Nebreda para investigar las metástasis de colon y mama
  
• 20 July 2010
  Qué!
  El IRB de Barcelona ficha al científico zamorano del CNIO Ángel Nebreda para ampliar el programa de cáncer
  
• 20 July 2010
  La Opinión de Zamora
  Un laboratorio de Barcelona ficha al oncólogo benaventano Ángel Nebreda