Publicacions Seleccionades

Clonal tracing with somatic epimutations reveals dynamics of blood ageing Scherer

M; Singh, I; Braun, MM; Szu-Tu, C; Sanchez Sanchez, P; (…) ; Rodriguez-Fraticelli, A*; Velten, L.*

Nature, 643, 478-487 (2025)

DOI: 10.1038/s41586-025-09041-8

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Sex and smoking bias in the selection of somatic mutations in human bladder

Calvet, F; Blanco, R; Muiños, F; Tretiakova, M; Latorre-Esteves, E.S; Fredrickson, J; Andrianova, M; Pellegrini, S; Rosendahl, A; Ramis-Zaldivar, JE; (…), Gonzalez-Perez, A; Lopez-Bigas, N*; Risques, RA.*

Nature, (2025) 647, 436-444

DOI: 10.1038/s41586-025-09521-x

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Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD

Garcia Cabau, C; Bartomeu, A; Tesei, G; (...); García, J; Battaglia, G; Lucas, J.J; Hervás, R; Lindorff Larsen, K; Méndez, R*; Salvatella, X.*

Nature, 637, 496-503 (2025)

DOI:  10.1038/s41586-024-08289-w

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TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages Henriques

A; Salvany-Celades, M; Nieto, P; Palomo-Ponce, S; Sevillano, M;

Hernando-Momblona, X; Middendorp-Guerra, E; Llanses Martinez, M; Haak, E; Nieto, J; Caratú, G; Marchese, D; Ruiz Gil, M; Tosi, S; Suckert, T; Badia-Ramentol, J;

Caballé-Mestres, A; Sanchez-Zarzalejo, C; Mateo, L; Tauriello, D; Riera, A; Sancho, E.; Stephan-Otto Attolini, C; Prados, A; Heyn, H; Batlle, E.

Nature Genetics, (2025)

DOI: 10.1038/s41588-025-02380-2

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Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer Sentís

I.; Melero, J.L.; Cebria-Xart, A.; (…); Mora, J.; Harari, A.; Nieto, J.C.; Avgustinova, A*; Heyn, H*.

Annals of Oncology, 36, 1096-1106 (2025)

DOI: 10.1016/j.annonc.2025.05.530

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A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer

Centonze, Al; Roura, AJ; (…); Colombelli, J; Fernández-Barral, A; Sancho, E; Stephan-Otto Attolini, C; (…); Cortina, C; Marti-Renom, MA; Batlle, E. 

Cancer Discovery, (2025)

DOI: 10.1158/2159-8290.CD-25-0679

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Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Singh, I; Fernandez-Perez, D; Sanchez, Pedro; Rodriguez-Fraticelli, A. 

Cell Stem Cell, 32, 564-580 (2025)

DOI: 10.1016/j.stem.2025.01.012

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DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy

Khalil, A; Supek, F.

Nature Communications, 16, 4209 (2025) 

DOI: 10.1038/s41467-025-59397-8

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Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Sanchez-Feutrie, M; Romero, M; Veiga, SR; Borras-Ferre, N; Berrow, N; (…) Palacin, M; Burcelin, R; Antonson, P; Gustafsson, JA; Zorzano, A.

Nature Communications, 16, 7033 (2025) 

DOI: 10.1038/s41467-025-62255-2

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Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse

Heras-Murillo, I; Mananes, D; Munne, P; Nunez, V; Herrera, J; Catala-Montoro, M; Alvarez, M; del Pozo, MA; Melero, I; Wculek, SK*; Sancho, D*.

Nature Communications, 16, 3369 (2025) 

DOI: 10.1038/s41467-025-58289-1

 

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A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations

Nadal-Ribelles, M*; Solé, C; Díez-Villanueva, A; Stephan-Otto Attolini, C; Matas, Y; Steinmetz, L; de Nadal, E*; Posas, F*.

Nature Communications, 16, 2645 (2025) 

DOI: 10.1038/s41467-025-57600-4

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Transcriptional heterogeneity shapes stress-adaptive responses in yeast

Nadal-Ribelles, M*; Lieb, G; Solé, C; Matas, Y; Szachnowski, U; Andjus, S; Quintana, M; Romo, M; Herrero, AG; Morillon, A; Pelet, S; de Nadal, E*; Posas, F*.

Nature Communications, 16, 2631 (2025) 

DOI: 10.1038/s41467-025-57911-6

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Drosophila and human Headcase define a new family of Ribonucleotide granule proteins required for stress response.

Ricolo, D; Casanova, J*, Giannios, P*.

Science Advances, 11 (2025)

DOI: 10.1126/sciadv.ads2086 

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Circadian clock communication during homeostasis and ageing

Mortimer T; Smith JG; Muñoz-Cánoves P; Aznar Benitah, S 

Nature Reviews Molecular Cell Biology, 26, 314-331 (2025)

DOI:  10.1038/s41580-024-00802-3

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Exposomal determinants of non-genetic plasticity in tumor initiation Carra

D; Maas, SCE; Seoane, JA.; Alonso-Curbelo, D.

Trends in Cancer, 11, 295-308 (2025)

DOI: 10.1016/j.trecan.2025.01.010

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The need to implement FAIR principles in biomolecular simulations

Amaro, RE; Aqvist, J; Bahar, I; Battistini, F; Bellaiche, A; Beltran, D; (…); Zacharias, M; Orozco, M

Nature Methods (2025)

DOI:  10.1038/s41592-025-02635-0

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Cross-priming in cancer immunology and immunotherapy

Luri-Rey, C; Teijeira, A; Wculek, SK; de Andrea, C; Herrero, C; Lopez-Janeiro, A; Rodríguez-Ruiz, ME; Heras, I; Aggelakopoulou, M; Berraondo, P; Sancho, D; Melero, I

Nature Reviews Cancer, 25, 4, 249-273 (2025)

DOI: 10.1038/s41568-024-00785-5

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Mutations that stick: Unexpected discovery of molecular glue mimicry

Whelan, R; José-Duran, F; Mayor-Ruiz, C.

Molecular Cell, 85, 1484-1486 (2025)

DOI: 10.1016/j.molcel.2025.03.017

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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

Sebé-Pedrós, A; Tanay, A; Lawniczak, MKN.; Arendt, D; Aerts, S; Archibald, J; Arnone, MI; (…) Gabaldón, T; (…); Technau, Ulrich; Wang, Bo; ,

Nature, 645, 877-885 (2025)

DOI:  10.1038/s41586-025-09312-4

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Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study

Rettkowski, J; Romero-Mulero, MC; Singh, I; (…); Rodriguez-Fraticelli, AE; Heidt, T; Cabezas-Wallscheid, N

Nature Cell Biology, 27, 591-604 (2025) 

DOI: 10.1038/s41556-025-01639-4

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Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology

Català-Castro, F; Ortiz-Vásquez, S; Martínez-Fernández, C; Pezzano, F; Garcia-Cabau, C; (...); Salvatella, X; Ruprecht, V; Frigeri, PA; Krieg, M

Nature Nanotechnology, 20, 411-420 (2025)

DOI: 10.1038/s41565-024-01830-y

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The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

Deota, S; Pendergast, JS; Kolthur-Seetharam, U; Esser, KA; Gachon, F; Asher, G; Dibner, C; Benitah, SA; Escobar, C; (…), J; Drucker, DJ; Panda, S

Nature Metabolism, 7, 454-468 (2025)

DOI: 10.1038/s42255-025-01237-6

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Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease Bao

Li-L; Yu, YQ; Gonzalez-Acera, M; (…); Zorzano, A; Becker, C. Science

Translational Medicine, 17, 781, eadn8699 (2025)

DOI: 10.1126/scitranslmed.adn8699

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The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells.

Plygawko AT; Stephan-Otto Attolini C; Pitsidianaki I; Cook DP; Darby AC; Campbell K.

Developmental Cell, 60, 429-446 (2025)

DOI: 10.1016/j.devcel.2024.10.011

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Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning

Larrañaga, E; Marin-Riera, M; (…); Batlle, E; Sharpe, J; Ojosnegros, S; Comelles, J; Martinez, E.

Nature Communications, 16, 382 (2025)

DOI: 10.1038/s41467-024-55651-7

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Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing

Perucca, A; Llonin, AG; (…); Colombelli, J; (…); Roca-Cusachs, P; Albanell, J; Trepat, Xr; Calon, A; Labernadie, A.

Nature Communications, 16, 1279 (2025)

DOI: 10.1038/s41467-025-56275-1

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Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

Martinez Garcia de la Torre, RA; Vallverdu, J; (…); Zorzano, A; Graupera, I; Moles, A; Coll, M; Affo, S; Sancho-Bru, P.

Nature Communications, 16, 1489 (2025)

DOI: 10.1038/s41467-025-56024-4

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A transient contractile seam promotes epithelial sealing and sequential assembly of body segments

Godeau, AL; Marin-Riera, M; (…); Colombelli, J; Sharpe, J; Martin-Blanco, E; Solon, J.

Nature Communications, 16, (2025)

DOI: 10.1038/s41467-025-58566-z

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