Philip Knobel

Research Group:

Genomic Instability and Cancer Laboratory

Unit:

ONCOLOGY

Position:

Alumni - Postdoctoral Fellow

Office:

EM01B43-44

Telephone:

+34 93 40 31197

Email:

philip.knobel@irbbarcelona.org

Left IRB Barcelona in July 2017

Selected group publications

CCNO mutations in NPH?

Núnez-Ollé M, Stracker TH and Gil-Gómez G.

Aging-us, 10 (2), 158-159 (2018)

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH and Nebreda AR.

Cancer Cell, 33 (6), 1094-1110. (2018)

Molecular basis of Tousled-Like Kinase 2 activation

Mortuza GB, Hermida D, Pedersen AK, Segura-Bayona S, López-Méndez B, Redondo P, Rüther P, Pozdnyakova I, Garrote AM, Muñoz IG, Villamor-Payà M, Jauset C, Olsen JV, Stracker TH and Montoya G.

Nat Commun, 9 (1), 2535 (2018)

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation

Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O and Stracker TH.

Nat Cell Biol, 20 (2), 162-174 (2018)

GEMC1 is a critical regulator of multiciliated cell differentiation

Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V and Stracker TH.

Embo J, 35 (9), 942-60 (2016)

NBS1 is required for macrophage homeostasis and functional activity in mice

Pereira-Lopes S, Tur J, Calatayud-Subias JA, Lloberas J, Stracker TH and Celada A.

Blood, (2015)

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele

Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM and Stracker TH.

Nucleic Acids Res, 43 (15), 7371-87 (2015)

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J and Stracker TH.

Nat Commun, 6 7676 (2015)

Systematic identification of molecular links between core and candidate genes in breast cancer

Arroyo R, Suñé G, Zanzoni A, Duran-Frigola M, Alcalde V, Stracker TH, Soler-López M and Aloy P.

J Mol Biol, 427 (6 Pt B), 1436-50 (2015)

ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

Chen WT, Ebelt ND, Stracker TH, Xhemalce B, Van Den Berg CL and Miller KM.

Elife, 4 (2015)

Regulation of USP28 deubiquitinating activity by SUMO conjugation

Zhen Y, Knobel PA, Stracker TH and Reverter D.

J Biol Chem, 289 (50), 34838-50 (2014)

The MRE11 complex: an important source of stress relief

Rein K and Stracker TH.